Risk factors and predicting health disorders in infants born from monocyesis after in vitro fertilization

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616-053.36- 092.11-036: 618.177-089.888.11
Authors: 

L.A. Pykhtina, O.M. Filkina, N.D. Gadzhimuradova, A.I. Malyshkina, S.B. Nazarov

Organization: 

Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkova, 109 Shuvandina Str., Ivanovo, 153045, Russian Federation

Abstract: 

Issues of health state and factors determining it in infants born due to in vitro fertilization (IVF) have been frequently discussed over recent years. The question yet to be answered is whether health disorders are related to burdened pre-morbid state of a mother as per extragenital and obstetric-gynecologic pathology or they are caused by IVF. Selective transfer of only one embryo has tended to increase recently, and, given this trend, specialists all around the world, and in our country as well, face a problem of detecting risk factors which cause health disorders in children born in monocyesis after IVF. Prognostic algorithm for most frequent pathologies is being worked out and it will help to implement targeted and differentiated approach to their prevention. We have completed clinical examination of infants during the first year of their life; all these infants were born in monocyesis after IVF (n=121). We have also questioned and interviewed their parents and analyzed data taken from infants' development records over a year as well. We have applied Wald sequential mathematical analysis to determine risk factors and create prognostic tables comprising most frequent somatic health disorders such as congenital abnormalities, iron-deficiency anemia, atopic dermatitis, absence of perinatal CNS damage compensation. We have detected that factors related to a mother's and newborn's health (extragenital morbidity, obstetric-gynecologic case history, pregnancy course) exert their influence on health disorders evolvement in such children during their first year of life; we have also shown that social factors and factors associated with IVF procedure don't have any statistical significance.

Keywords: 
risk factors, health disorders prediction, children from monocyesis, IVF, congenital abnormalities, iron-deficiency anemia, atopic dermatitis, perinatal CNS damages
Pykhtina L.A., Filkina O.M., Gadzhimuradova N.D., Malyshkina A.I., Nazarov S.B. Risk factors and predict-ing health disorders in infants born from monocyesis after in vitro fertilization. Health Risk Analysis, 2017, no. 1, pp. 56–65. DOI: 10.21668/health.risk/2017.1.07.eng
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