Violation of homeostasis of the main types of exchange and immune resistance status in children with subclinical hypovitaminosis in conditions of exposure to chemical environmental factors

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DOI: 
10.21668/health.risk/2016.1.09.eng
Authors: 

A.M. Yambulatov2, O.U. Ustinova1,3, K.P. Luzhetskiy1,3

Organization: 

1 FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies” of Rospotrebnadzor, 82, Monastyrskaya st., Perm, 614045, Russia
2 Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Perm region, 50, Kuibysheva st., Perm, 614016, Russia
3 FSBEI HPE «Perm State National Research University", 15, Bukireva st., Perm, 614990, Russia

Abstract: 

The study of the chemical substances’ content of anthropogenic origin in children with subclinical polyhypovitaminosis was conducted. It was found that a deficiency of vitamins A, C, E, B6 and B12 increases the risk of developing of elevated concentrations of organic substances of technogenic origin in blood in 1.4–6.9 times. In children with subclinical polyhypovitaminosis and high blood phenol, formaldehyde, aromatic hydrocarbons, and organ chlorine compounds increases the tension of erythropoiesis, decreases the activity of proliferating processes of lympfomonocytic germ cell factors of nonspecific resistance. Even subclinical forms of polyhypovitaminosis on the background of high content of organic compounds in the blood of children are accompanied by a slowdown of protein and carbohydrate metabolism, depletion of antioxidant defense system of reserves and shortage of energy metabolism. Developing disorders of fat metabolism in children with subclinical polyhypovitaminosis occur against a background of strained reactions of hormonal regulation that, in case of the progressive course may pose a threat to the early development of cardiovascular disease in older age groups.

Keywords: 
children, subclinical polyhypovitaminosis, chemicals, man-made origin, metabolism, immunoresistance
Yambulatov A.M., Ustinova O.U. , Luzhetskiy K.P. Violation of homeostasis of the main types of exchange and immune resistance status in children with subclinical hypovitaminosis in conditions of exposure to chemical environmental factors. Health Risk Analysis, 2016, no. 1, pp. 77-86. DOI: 10.21668/health.risk/2016.1.09.eng
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