Identification of methyl tert-butyl ether in human blood with chromatography-mass-spectrometric method

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UDC: 
543.51
DOI: 
10.21668/health.risk/2014.2.09.eng
Authors: 

T.S. Ulanova, T.V. Nurislamova

Organization: 

Federal Budget Scientific Institution “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”, Russian Federation, Perm, 82 Monastyrskaya st., 614045

Abstract: 

This article details the applying of GC-MS for accurate identification and study the fragmentation of ionized molecules of methyl tert-butyl ether in human blood. Basing on the reception of mass spectrum of ions of methyl tert-butyl ether the structure, molecular weight, elemental composition of a molecule of methyl tert-butyl ether are defined. The characteristic ions (primary and confirming ions) of methyl tert-butyl ether are detected and the chromatographic retention time is determined.

In the process of performing of identification of methyl tret-butyl ether in a blood sample on the mass spectrogram the peak is set which is the result of overlap of several individual peaks of the compounds-isomers with the identical retention times: 2- methylpentane, methyl tert-butyl ether and 3-methyl pentane. To eliminate low resolution in the studies two consecutive capillary columns were used.

Keywords: 
methyl tert-butyl ether, chromatographic-mass-spectrometric method, characteristic ions, mass-spectrum, mass-selective detector
Ulanova T.S., Nurislamova T.V. Identification of methyl tert-butyl ether in human blood with chromatography-mass-spectrometric method. Health Risk Analysis, 2014, no. 2, pp. 76-82
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