Impact of post-COVID-19 symptoms on health and quality of life: A study from Vietnam

UDC: 
616.9; 578.834.1; 314.17
Authors: 

Hue Vu Thi1,2, Anh Dao Ngo1, Nhat-Le Bui1,2, Yen Vy Nguyen Thi1,2, Thuc Quyen Nguyen1,2,3, Hoang Lam Nguyen1, Thuy Duong Vu1, Dinh-Toi Chu1,2

Organization: 

1The Interdisciplinary Research Group on Biomedicine and Health, International School, Vietnam National University, Hanoi, Vietnam
2Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam
3The Interdisciplinary Research Group on Science, Technology, Innovation and Society, International School, Vietnam National University, Hanoi, Vietnam

Abstract: 

This study aimed to describe the status of post-COVID-19 symptoms and their impact on the quality of life in Vietnamese people.

The secondary analysis was performed on the data from a cross-sectional study conducted in Vietnam in 2022.

Of the 972 participants, 76.75 % reported experiencing at least one COVID-19 symptom. Respiratory and heart symptoms and neurological symptoms were the types of symptoms that were reported the most. An increase in post-COVID-19 symptoms has an association with an increased number of problems in life quality. Pain/discomfort and anxiety/depression were the most common problems regarding the quality of life (35 % and 24.5 %, respectively). Problems with quality of life were significantly associated with all listed post-COVID-19 symptoms, in which depression and anxiety showed the highest impact.

The high prevalence of post-COVID-19 symptoms and their impact on quality of life suggests that the effects of COVID-19 can persist after initial recovery, even in the long term.

Keywords: 
post-COVID-19 symptoms, impact, health, quality of life, Vietnam
Hue Vu Thi, Anh Dao Ngo, Nhat-Le Bui, Yen Vy Nguyen Thi, Thuc Quyen Nguyen, Hoang Lam Nguyen, Thuy Duong Vu, Dinh-Toi Chu. Impact of post-COVID-19 symptoms on health and quality of life: a study from Vietnam. Health Risk Analysis, 2026, no. 1, pp. 115–124. DOI: 10.21668/health.risk/2026.1.11.eng
References: 
  1. Teoli D., Bhardwaj A. Quality Of Life. Treasure Island (FL), StatPearls Publ., 2023.
  2. Malik P., Patel K., Pinto C., Jaiswal R., Tirupathi R., Pillai S., Patel U. Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis. J. Med. Virol., 2022, vol. 94, no. 1, pp. 253–262. DOI: 10.1002/jmv.27309
  3. National Center for Immunization and Respiratory Diseases (U.S.). Division of Viral Diseases. Long COVID or Post-COVID Conditions. CDC Stacks, 2023.
  4. Lechner-Scott J., Levy M., Hawkes C., Yeh A., Giovannoni G. Long COVID or post COVID-19 syndrome. Mult. Scler. Relat. Disord., 2021, vol. 55, pp. 103268. DOI: 10.1016/j.msard.2021.103268
  5. Jimeno-Almazán A., Pallarés J.G., Buendía-Romero Á., Martínez-Cava A., Franco-López F., Sánchez-Alcaraz Martínez B.J., Bernal-Morel E., Courel-Ibáñez J. Post-COVID-19 Syndrome and the Potential Benefits of Exercise. Int. J. Environ. Res. Public Health, 2021, vol. 18, no. 10, pp. 5329. DOI: 10.3390/ijerph18105329
  6. Zięba N., Stryjewska-Makuch G., Goroszkiewicz K., Zieliński M., Dadok A., Pietrzyk B., Gajewska J., Miśkiewicz-Orczyk K., Lisowska G. Assessment of life quality and health perception among recovered COVID-19 patients: multivariate analysis – own material and a review of previous reports on life quality assessment among convalescents. Med. Pr., 2022, vol. 73, no. 6, pp. 449–456. DOI: 10.13075/mp.5893.01297
  7. Chu D.-T., Thi H.V., Thi Y.V.N., Vu T.D., Tran L.T., Bui Q.C., Thi C.H., Than T.V. An initial assessment of status of post-COVID-19 symptoms in Vietnames e students. J. Adv. Biotechnol. Exp. Ther., 2024, vol. 7, no. 2, pp. 378–384.
  8. Nasserie T., Hittle M., Goodman S.N. Assessment of the Frequency and Variety of Persistent Symptoms Among Patients With COVID-19: A Systematic Review. JAMA Netw. Open, 2021, vol. 4, no. 5, pp. e2111417. DOI: 10.1001/jamanetworkopen.2021.11417
  9. Joli J., Buck P., Zipfel S., Stengel A. Post-COVID-19 fatigue: A systematic review. Front. Psychiatry, 2022, vol. 13, pp. 947973. DOI: 10.3389/fpsyt.2022.947973
  10. Rousseau A.-F., Minguet P., Colson C., Kellens I., Chaabane S., Delanaye P., Cavalier E., Chase J.G. [et al.]. Post-intensive care syndrome after a critical COVID-19: cohort study from a Belgian follow-up clinic. Ann. Intensive Care, 2021, vol. 11, no. 1, pp. 118. DOI: 10.1186/s13613-021-00910-9
  11. van Veenendaal N., van der Meulen I.C., Onrust M., Paans W., Dieperink W., van der Voort P.H.J. Six-Month Outcomes in COVID-19 ICU Patients and Their Family Members: A Prospective Cohort Study. Healthcare (Basel), 2021, vol. 9, no. 7, pp. 865. DOI: 10.3390/healthcare9070865
  12. Vu M.Q., Tran T.T.P., Hoang T.A., Khuong L.Q., Hoang M.V. Health-related quality of life of the Vietnamese during the COVID-19 pandemic. PLoS One, 2020, vol. 15, no. 12, pp. e0244170. DOI: 10.1371/journal.pone.0244170
  13. Ellul M.A., Benjamin L., Singh B., Lant S., Michael B.D., Easton A., Kneen R., Defres S. [et al.]. Neurological associations of COVID-19. Lancet Neurol., 2020, vol. 19, no. 9, pp. 767–783. DOI: 10.1016/S1474-4422(20)30221-0
  14. Mutiawati E., Kusuma H.I., Fahriani M., Harapan H., Syahrul S., Musadir N. Headache in Post-COVID-19 Patients: Its Characteristics and Relationship with the Quality of Life. Medicina (Kaunas), 2022, vol. 58, no. 10, pp. 1500. DOI: 10.3390/medicina58101500
  15. Malesevic S., Sievi N.A., Schmidt D., Vallelian F., Jelcic I., Kohler M., Clarenbach C.F. Physical Health-Related Quality of Life Improves over Time in Post-COVID-19 Patients: An Exploratory Prospective Study. J. Clin. Med., 2023, vol. 12, no. 12, pp. 4077. DOI: 10.3390/jcm12124077
  16. Smith P., De Pauw R., Van Cauteren D., Demarest S., Drieskens S., Cornelissen L., Devleesschauwer B., De Ridder K., Charafeddine R. Post COVID-19 condition and health-related quality of life: a longitudinal cohort study in the Belgian adult population. BMC Public Health, 2023, vol. 23, no. 1, pp. 1433. DOI: 10.1186/s12889-023-16336-w
  17. Mazza M.G., Palladini M., Poletti S., Benedetti F. Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment. CNS Drugs, 2022, vol. 36, no. 7, pp. 681–702. DOI: 10.1007/s40263-022-00931-3
  18. Harenwall S., Heywood-Everett S., Henderson R., Godsell S., Jordan S., Moore A., Philpot U., Shepherd K. [et al.]. Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation. J. Prim. Care Community Health, 2021, vol. 12, pp. 21501319211067674. DOI: 10.1177/21501319211067674
Received: 
08.12.2025
Approved: 
16.02.2026
Accepted for publication: 
26.03.2026

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