The impact of air, water and soil pollution on mortality and morbidity of certain classes of diseases and nosologies in the Republic of Tatarstan (2019–2023)

UDC: 
614.44
Authors: 

R.N. Khairullin1, М.А. Patyashina2, А.А. Titova2, Ch.I. Ildarkhanova1, G.N. Ershova1

Organization: 

1Interregional Clinical Diagnostic Center, 12a Karbysheva Str., Kazan, 420101, Russian Federation
2Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing, Tatarstan Regional Office, 30 Bolshaya Krasnaya Str., Kazan, 420111, Russian Federation

Abstract: 

We have examined influence exerted by eight microbiological and chemical environmental factors on mortality, primary incidence and disease prevalence per 19 disease classes in 45 municipalities in Tatarstan, including children, working age population and elderly people, over 2019–2023. The study aimed to identify priority environmental risk factors causing medical-demographic losses of the population per specific classes of diseases and nosologies in Tatarstan. The study tasks included establishing correlations between environmental and medical-demographic factors as well as their strength; building predictive regression models; assessing regression coefficients of additional mortality and morbidity risks.

The results obtained by comparative analysis of influence exerted by ambient air, water and soil quality in Tatarstan confirmed the existing national trends in Russia as regards associations between mortality and morbidity and chemical pollution in ambient air, water supply deviating from the existing sanitary-epidemiological rules and standards, soils not conforming to safe standards per microbiological indicators; in addition, we established some health risks specific for Tatarstan. The greatest number of strong correlations was established for ambient air quality; a smaller number of medium correlations was established for water quality; the smallest number of correlations was established for soil quality. Children remain the most susceptible population group as regards primary incidence and disease prevalence. Multifactorial models established that additional risk of environment-associated incidence ranged between 44 and 67 % for children, equaled 57 % for working age population and 30 % for people older than working age per the existing mean morbidity rates per various classes of diseases.

A strong direct correlation was established between incidence of neoplasms in children and the proportion of ambient air samples containing NO2 and NH3 in levels beyond the maximum permissible concentration; the same correlation was established between NH3 levels exceeding the maximum permissible concentration and prevalence/incidence of complications of pregnancy and childbirth among working-age women. Regarding mortality, we revealed correlations of varying strength; a strong non-linear correlation was found between all-cause mortality among people older than 80 years and the proportion of air samples containing NO2 in levels beyond its maximum permissible concentration. Predictive models allow us to calculate a positive effect of modifying environmental factors for reducing additional risk of population morbidity and mortality.

Keywords: 
sanitary and epidemiological well-being, environmental factors, risk modification, mortality, primary incidence, disease prevalence, correlation and regression analysis, predictive model
Khairullin R.N., Patyashina М.А., Titova А.А., Ildarkhanova Ch.I., Ershova G.N. The impact of air, water and soil pollution on mortality and morbidity of certain classes of diseases and nosologies in the Republic of Tatarstan (2019–2023). Health Risk Analysis, 2025, no. 3, pp. 13–23. DOI: 10.21668/health.risk/2025.3.02.eng
References: 
  1. Kim H.D., Oh J., Myung J., Han C., Bae H.J., Kim S., Hong Y.-C., Lim Y.-H., Lee D.-W. Long-term exposure to air pollution and incident Alzheimer’s disease among older adults: evidence from a large-scale retrospective cohort in Korea. Environ. Sci. Pollut. Res. Int., 2025, vol. 32, no. 3, pp. 18349–18365. DOI: 10.1007/s11356-025-36723-7
  2. Tian F., Wei S., Qian Z., Zhao J., Wang Y., Ho K.-F., Arnold L.D., Burroughs T., Lin H. Ambient air pollution exposure accelerates the occurrence of 78 non-communicable chronic diseases: an accelerated failure time analysis of a nationwide cohort. GeroScience, 2025. DOI: 10.1007/s11357-025-01806-3
  3. Yorifuji T., Kashima S., Tsuda T., Ishikawa-Takata K., Ohta T., Tsuruta K., Doi H. Longterm exposure to traffic-related air pollution and the risk of death from hemorrhagic stroke and lung cancer in Shizuoka, Japan. Sci. Total Environ., 2013, vol. 443, pp. 397–402. DOI: 10.1016/j.scitotenv.2012.10.088
  4. Weichenthal S., Pinault L.L., Burnett R.T. Impact of oxidant gases on the relationship between outdoor fine particulate air pollution and nonaccidental, cardiovascular, and respiratory mortality. Sci. Rep., 2017, vol. 7, no. 1, pp. 16401. DOI: 10.1038/s41598-017-16770-y
  5. Tonne C., Wilkinson P. Long-term exposure to air pollution is associated with survival following acute coronary syn-drome. Eur. Heart J., 2013, vol. 34, no. 17, pp. 1306–1311. DOI: 10.1093/eurheartj/ehs480
  6. Hart J.E., Garshick E., Dockery D.W., Smith T.J., Ryan L., Laden F. Long-term ambient multipollutant exposures and mortality. Am. J. Respir. Crit. Care Med., 2011, vol. 183, no. 1, pp. 73–78. DOI: 10.1164/ rccm.200912-1903OC
  7. Hart J.E., Rimm E.B., Rexrode K.M., Laden F. Changes in traffic exposure and the risk of incident myocardial infarction and all-cause mortality. Epidemiology, 2013, vol. 24, no. 5, pp. 734–742. DOI: 10.1097/EDE.0b013e31829d5dae
  8. Turner M.C., Jerrett M., Pope C.A. 3rd, Krewski D., Gapstur S.M., Diver W.R., Beckerman B.S., Marshall J.D. [et al.]. Long-term ozone exposure and mortality in a large prospective study. Am. J. Respir. Crit. Care Med., 2016, vol. 193, no. 10, pp. 1134–1142. DOI: 10.1164/rccm.201508-1633OC
  9. Carey I.M., Atkinson R.W., Kent A.J., van Staa T., Cook D.G., Anderson H.R. Mortality associations with long-term ex-posure to outdoor air pollution in a national English cohort. Am. J. Respir. Crit. Care Med., 2013, vol. 187, no. 11, pp. 1226–1233. DOI: 10.1164/rccm.201210-1758OC
  10. Associations of long-term average concentrations of nitrogen dioxide with mortality: a report by the Committee on the Medical Effects of Air Pollutants. London, Public Health England, 2018, 128 p. Available at: https://assets.publishing.service.gov.uk/government/uploads/system/uploa... (July 25, 2025).
  11. Schneider A., Cyrys J., Breitner S., Kraus U., Peters A. Quantifizierung von umweltbedingten Krankheitslasten aufgrund der Stickstoffdioxid-Exposition in Deutschland [Quantification of environmental burdens of disease due to nitrogen dioxide exposure in Germany]. Dessau-Roßlau, Umweltbundesamt, 2018, 172 p. Available at: https://www.umweltbundesamt.de/sites/default/files/medien/421/publikatio... (July 25, 2025).
  12. Turnock S.T., Allen R.J., Andrews M., Bauer S.E., Deushi M., Emmons L., Good P., Horowitz L. [et al.]. Historical and future changes in air pollutants from CMIP6 models. Atmos. Chem. Phys., 2020, vol. 20, no. 23, pp. 14547–14579. DOI: 10.5194/acp-20-14547-2020
  13. Fatkhutdinova L.M., Skorokhodkina O.V., Yapparova L.I., Khakimova M.R., Rakhimzyanov A.R., Ablyaeva A.V., Noskov A.I., Gabidinova G.F. [et al.]. The effect of fine suspended particles in the atmospheric air on the formation and course of the T2 endotype of bronchial asthma: a case-control study. Gigiena i sanitariya, 2022, vol. 101, no. 12, pp. 1469–1475. DOI: 10.47470/0016-9900-2022-101-12-1469-1475 (in Russian).
  14. The measurement and monitoring of water supply, sanitation and hygiene (WASH) affordability: A missing element of monitoring of Sustainable Development Goal (SDG) targets 6.1 and 6.2. New York, UNICEF, WHO, 2021, 121 p. Available at: https://washdata.org/sites/default/files/2021-05/unicef-who-2021-afforda... (August 04, 2025).
  15. Ranasinghe S.J.G., Han Z., Perera T., Tun T., Wang C., Zhang Y., Yang M. Opportunistic Pathogen and Virulence Factor Dynamics Along Stored Manure, Receiving Soil and Green Leaf Continua in Wet Zone of Sri Lanka. Water Air Soil Pollut., 2025, vol. 236, pp. 701. DOI: 10.1007/s11270-025-08358-4
  16. Molla M.O.F., Kabir M.A., Hossain M.K., Jahan M.S., Khatun M.S., Kumar S., Islam R. Groundwater quality as-sessment and health risk evaluation for schoolchildren in Mujibnagar, Bangladesh: safe consumption guidelines using artificial neural network modeling. Environ. Geochem. Health, 2025, vol. 47, no. 8, pp. 324. DOI: 10.1007/s10653-025-02627-1
  17. Rakhmatullina L.R., Suleymanov R.A., Valeev T.K., Baktybaeva Z.B., Rakhmatullin N.R. Assessing health risks as-sociated with drinking water quality (on the example of regions in bashkortostan where oil fields are located). Health Risk Analysis, 2021, no. 2, pp. 33–40. DOI: 10.21668/health.risk/2021.2.03.eng
  18. Patyashina M.A., Titova A.A., Pankratova O.N. Osobennosti vodosnabzheniya na territorii Respubliki Tatarstan po dannym sotsial'no-gigienicheskogo monitoringa [Features of water supply in the Republic of Tatarstan according to social and hygienic monitoring data]. Fundamental'nye i prikladnye aspekty analiza riska zdorov'yu naseleniya: Materialy vserossiiskoi nauchno-prakticheskoi internet-konferentsii molodykh uchenykh i spetsialistov Rospotrebnadzora s mezhdunarodnym uchastiem. In: A.Yu. Popova, N.V. Zaitseva eds. Perm, October 8–12, 2018. Perm, Perm National Research Polytechnic University Publ., 2018, pp. 76–78 (in Russian).
  19. Mamonova I.A., Erdniev L.P., Kosheleva I.S., Kuzyanov D.A., Dolich V.N., Gusev Yu.S., Komleva N.E., Mikerov A.N. Health effects of consuming artesian water supplied through the centralized distribution network in the population of arid areas of the Saratov Region. ZNiSO, 2024, vol. 32, no. 1, pp. 49–57. DOI: 10.35627/2219-5238/2024-32-1-49-57 (in Russian).
  20. Zaitseva N.V., May I.V., Klein S.V., Kiryanov D.A. Methodological aspects and results of estimation of demographic loss associated with harmful influence of environment factors and preventive activities of Rospotrebnadzor in regions of the Russian Federation. ZNiSO, 2018, no. 4 (301), pp. 15–20. DOI: 10.35627/2219-5238/2018-301-4-15-20
  21. Huangfu P., Atkinson R. Long-term exposure to NO2 and O3 and all-cause and respiratory mortality: a systematic review and meta-analysis. Environ. Int., 2020, vol. 144, pp. 105998. DOI: 10.1016/j.envint.2020.105998
Received: 
07.08.2025
Approved: 
17.09.2025
Accepted for publication: 
28.09.2025

You are here