Neuroantibodies as risk markers for the development of autoimmune processes in case of vibration disease

UDC: 
616-001.34: 616.8: 616.1: 612.017.1
DOI: 
10.21668/health.risk/2025.1.12.eng
Authors: 

N.P. Chistova, G.M. Bodienkova, E.V. Boklazhenko

Organization: 

East-Siberian Institute of Medical and Ecological Research, 3, 12a microdistrict, Angarsk, 665827, Russian Federation

Abstract: 

The aim of the study was to identify the features of changes in the content of neuroantibodies reflecting the risk of developing autoimmune processes in patients with hand-arm vibration syndrome (HAVS), complicated and uncomplicated arterial hyperten-sion (AH).

A retrospective study was conducted in a sample of men aged 40 to 60 years with a diagnosed hand-arm vibration syn-drome caused by local vibration and in a group comparable per sex and age, including people who worked in conditions that excluded contact with occupational physical factors. Groups of patients with HAVS, complicated and uncomplicated AH have been identified. The levels of autoantibodies to specialized structures of nervous tissue and neurotransmitters were determined in all the examined participants using the ELI-N-Test ("Immunculus", Moscow).

The study revealed an increase in the levels of neuronal AT (MBP, S-100, GFAP, NF-200, V-Ca-channel, Glu-R, DA-R, M-OR, B-end) in patients with HAVS, both burdened and uncomplicated hypertension, relative to the comparison group. At the same time, the levels of AT to the opiate M-OR receptors in people with HAVS who were not burdened with hypertension were statistically significantly higher than in patients with comorbid pathology (p = 0.04). Discriminant analysis showed that individuals with HAVS burdened with hypertension were characterized by a decrease in the levels of AT to gamma-aminobutyric acid receptors (F = 8.5, p = 0.001) and to the myelin basic protein (F = 13.7, p = 0.001) in comparison with patients with HAVS without hypertension. The neuron-neuron interaction disorder in patients with AH was manifested by a mismatch of correlations between the levels of autoantibodies to S-100 protein and myelin basic protein (R = 0.29, p > 0.05), voltage-dependent Ca-channel (R = 0.41, p > 0.05), dopamine receptors (R = 0.42, p > 0.05), serotonin (R = 0.33, p > 0.05) and opiates (R = 0.32, p > 0.05).

Thus, increased levels of neuronal AT (MBP, S-100, GFAP, NF-200, V- Ca-channel, Glu-R, DA-R, M-OR, B-end) in patients with HAVS, both burdened and uncomplicated hypertension, are markers reflecting the risk of developing autoimmune processes upon exposure to vibration. The reported lower levels of AT to the GABA receptor and the myelin basic protein in patients with HAVS burdened with hypertension, when compared with those with HAVS without hypertension, are apparently due to the peculiarities of the clinical course of the disease and the formation of immune tolerance to these proteins. The obtained results can be used in carrying out diagnostic, preventive and therapeutic measures for people with HAVS, including in the presence of comorbid pathology.

Keywords: 
occupational stress, hand-arm vibration syndrome, arterial hypertension, immune system, nervous system, autoantibodies, gamma-aminobutyric acid (GABA), myelin basic protein, opiate receptors
Chistova N.P., Bodienkova G.M., Boklazhenko E.V. Neuroantibodies as risk markers for the development of autoimmune processes in case of vibration disease. Health Risk Analysis, 2025, no. 1, pp. 128–136. DOI: 10.21668/health.risk/2025.1.12.eng
References: 
  1. Tatarovskaya N.A. Arterial hypertension as a risk factor of vascular disorders of the patients with vibration disease. Aspirantskie chteniya 2016. Materialy nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem «Molodye uchenye – ot tekhnologii XXI veka k prakticheskomu zdravookhraneniyu», 2016, pp. 69–70 (in Russian).
  2. NCD Risk Factor Collaboration. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. The Lancet, 2021, vol. 398, no. 10304, pp. 957–980. DOI: 10.1016/S0140-6736(21)01330-1
  3. Bodienkova G.M., Boklazhenko E.V. Comparative assessment of neurochemical indicators in patients with occupational pathology due to physical and chemical factors. Neirokhimiya, 2021, vol. 38, no. 4, pp. 385–390. DOI: 10.31857/S1027813321040026 (in Russian).
  4. Usmanova D.D. The role of neurotrophic factors in the pathogenesis of chronic cerebral ischemia. Meditsinskie novosti, 2015, no. 9, pp. 66–67 (in Russian).
  5. Odinak M.M., Tsygan N.V., Ivanov A.M., Kamilova T.A., Nikitin V.Yu., Meshkova M.E. Protein s100β – biomarker of brain injury. Bulletin of the Russian Military Medical Academy, 2011, no. 1 (33), рр. 210–214 (in Russian).
  6. Bodienkova G.M., Boklazhenko E.V., Katamanova E.V. Clinical value of regulatory autoantibodies in development of neurointoxication with metallic mercury vapours. Bulletin of the East Siberian Scientific Center SB RAMS, 2012, no. 2–1 (84), pp. 20–23 (in Russian).
  7. Wenzel U., Turner J.E., Krebs C., Kurts C., Harrison D.G., Ehmke H. Immune Mechanisms in Arterial Hypertension. J. Am. Soc. Nephrol., 2016, vol. 27, no. 3, pp. 677–686. DOI: 10.1681/ASN.2015050562
  8. Vertkin A.L., Khovasova N.O. Komorbidnost' – novaya patologiya. Tekhnologii ee profilaktiki i lecheniya [Comorbidity is a new pathology. Technologies of its prevention and treatment]. Arkhiv" vnutrennei meditsiny, 2013, no. 4, pp. 68–74 (in Russian).
  9. Timakova A.Yu., Saydaeva M.I., Skirdenko Yu.P. Pseudoresistant arterial hypertension: causes and difficulties of di-agnosis. Nauchnoe obozrenie. Meditsinskie nauki, 2020, no. 1, pp. 36–41 (in Russian).
  10. Poterjaeva E.L., Fedina R.G., Hasnulin V.I. Industrial vibration – negative stress factor influencing men’ hypophysial-suprarenal system. Byulleten' nauchnogo soveta «Mediko-ekologicheskie problemy rabotayushchikh», 2007, no. 2, pp. 60–62 (in Russian).
  11. Baraeva R.A., Strizhakov L.A., Borzykh Y.I. Factors of humoral immunity in the combined course of vibration disease and hypertension. Meditsina truda i promyshlennaya ekologiya, 2019, no. 9, pp. 558–559. DOI: 10.31089/1026-9428-2019-59-9-558-559 (in Russian).
  12. Babanov S.A., Baraeva R.A., Strizhakov L.A., Moiseev S.V., Fomin V.V. The state of cytokine regulation and endo-thelial dysfunction in the combined course of vibration disease and arterial hypertension. Terapevticheskii arkhiv, 2021, vol. 93, no. 6, pp. 693–698. DOI: 10.26442/00403660.2021.06.200880 (in Russian).
  13. Zaichik A.M., Poletaev A.B., Churilov L.P. Natural autoantibodies, immunological theories and preventive medicine. Vestnik Sankt-Peterburgskogo universiteta. Meditsina, 2013, no. 2, pp. 3–16 (in Russian).
  14. Lishmanov Y.B., Maslov L.N., Naryzhnaya N.Y., Pei J., Kolar F., Zhang Y., Portnichenko A.G., Wang H. Endoge-nous opioid system as a mediator of acute and long-term adaptation to stress. Prospects for clinical use of opioid peptides.
    Annals of the Russian Academy of Medical Sciences, 2012, vol. 67, no. 6, pp. 73–82 (in Russian).
  15. Zhukova N.V., Mavrutenkov V.V., Ushakova G.A. Neurospecific protein s100b – a universal biochemical marker of damage. Part I. General issues (history, genetics, biochemistry, physiology). Klinicheskaya infektologiya i parazitologiya, 2014, no. 4 (11), pp. 53–64 (in Russian).
  16. Hamon M., Blier P. Monoamine neurocircuitry in depression and strategies for new treatments. Prog. Neuropsycho-pharmacol. Biol. Psychiatry, 2013, vol. 45, pp. 54–63. DOI: 10.1016/j.pnpbp.2013.04.009
  17. Astakhin A.V., Evlasheva O.O., Levitan B.N. Clinical and diagnostic value of myelin basic protein and neuron specific enolase in medical practice. Astrakhanskii meditsinskii zhurnal, 2016, vol. 11, no. 4, pp. 9–17 (in Russian).
  18. Shimada M., Hasegawa T., Nishimura C., Kan H., Kanno T., Nakamura T., Matsubayashi T. Anti-Hypertensive Effect of Gamma-Aminobutyric Acid (GABA)-Rich Chlorella on High-Normal Blood Pressure and Borderline Hypertension in Placebo-Controlled Double Blind Study. Clin. Exp. Hypertens., 2009, vol. 31, no. 4, pp. 342–354. DOI: 10.1080/10641960902977908
  19. Mei L., Zhang J., Mifflin S. Hypertension alters GABA receptor-mediated inhibition of neuronsin the nucleus of the solitary tract. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2003, vol. 285, no. 6, pp. 1276–1286. DOI: 10.1152/ajpregu.00255.2003
  20. Rukavishnikov V.S., Pankov V.A., Kuleshova M.V., Katamanova E.V., Kartapol'tseva N.V., Rusanova D.V., Bodienkova G.M., Titov E.A. On theory of sensory conflict under exposure to physical factors: main principles and concepts of formation. Meditsina truda i promyshlennaya ekologiya, 2015, no. 4, pp. 1–6 (in Russian).
  21. Laporte J.P., Faulkner M.E., Gong Z., Akhonda M.A.B.S., Ferrucci L., Egan J.M., Bouhrara M. Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study. Hypertension, 2023, vol. 80, no. 8, pp. 1728–1738. DOI: 10.1161/HYPERTENSIONAHA.123.21012
  22. Trofimova O., Latypova A., DiDomenicantonio G., Lutti A., de Lange A.-M.G., Kliegel M., Stringhini S., Marques-Vidal P. [et al.]. Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain. Commun. Biol., 2023, vol. 6, no. 1, pp. 392. DOI: 10.1038/s42003-02
Received: 
29.01.2025
Approved: 
19.03.2025
Accepted for publication: 
27.03.2025

You are here

Home