Risk of declining vaccine-induced immunity stress to measles, diphtheria and pertussis in children under exposure to airborne metals and aromatic hydrocarbons

UDC: 
613.95:614.47
DOI: 
10.21668/health.risk/2024.4.09.eng
Authors: 

N.V. Zaitseva1,2, О.Yu. Ustinova1,2, V.G. Makarova1, S.L. Valina1, I.Е. Shtina1

Organization: 

1Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation
2Perm State University, 15 Bukireva St., Perm, 614068, Russian Federation

Abstract: 

Vaccine-induced immunity stress is largely determined by safety of the environment. The aim of this study was to estimate vaccine-induced immunity stress to measles, diphtheria and pertussis in children under airborne exposures and its relationship with levels of metals and aromatic hydrocarbons in patients’ blood.

The observation group was made of 417 children aged 6–17 years who lived in an area with ambient Mn, Cr, Ni and benzene levels equal to 1.0–13.8 average annual MPLs. The reference group included 196 children who lived in a tentatively safe area. The children were selected using the following criteria: completed vaccination / re-vaccination against preventable infections; living for more than 3 years in a selected area; absence of any disease in its decompensation state or ARVI; provided informed consent to participation. Chemical-analytical tests to identify levels of chemicals in blood were conducted in conformity with the valid methodical guidelines. Levels of vaccine-induced antibodies were identified by ELISA tests with their results interpreted in accordance with the requirements provided with employed test-systems.

The study established health risks in the area where the observation group lived; if expressed through hazard indexes, they amounted to 4.3 (alerting risk) for the immune system and 6.8 (high risk) for blood. A direct correlation was established between impaired vaccine-induced immunity to measles and elevated Mn and benzene levels (R2 = 0.19–0.26; b0 = (-1.19) – (-3.10); b1 = 32.50–39.59; р < 0.001); diphtheria and elevated Mn, Cr and Ni levels (R2 = 0.13–0.78; b0 = (-2.95) – (-4.19) b1 = 85.22–302.60; р < 0.001)); pertussis and elevated Mn level (R2 = 0.19; b0 = -1.19; b1 = 39.59; р < 0.001). Mn (0.0210 ± 0.0012 µg/cm3) and benzene (0.00072 ± 0.00020 µg/cm3) levels resulted in 1.7 times lower levels of JgG to measles and thrice as high likelihood of low seroprotection (OR = 3.0; CI = 1.68–5.31). Elevated levels of Mn, Ni (0.0057 ± 0.0007 µg/cm 3) and Cr (0.0061 ± 0.0008 µg/cm 3)were associated with 1.8 times lower levels of antibodies to diphtheria and 4 times higher likelihood of low seroprotection in primary schoolchildren (OR = 3.92; CI = 1.10–13.97). Mn occurrence in blood reduced levels of antibodies to pertussis by 1.4 times and increased likelihood of impaired specific immunity by 1.8 times (OR = 1.77; CI = 1.25–2.51). Creation of high-level vaccine-induced immunity to preventable infections in children with metals and aromatic hydrocarbons in blood requires serologic monitoring, additions made in the National calendar for preventive vaccination and implementation of specialized medical and preventive technologies.

Keywords: 
vaccine-induced immunity, stress dynamics, children, measles, pertussis, diphtheria, metals, aromatic hydrocarbons
Zaitseva N.V., Ustinova О.Yu., Makarova V.G., Valina S.L., Shtina I.Е. Risk of declining vaccine-induced immunity stress to measles, diphtheria and pertussis in children under exposure to airborne metals and aromatic hydrocarbons. Health Risk Analysis, 2024, no. 4, pp. 97–112. DOI: 10.21668/health.risk/2024.4.09.eng
References: 
  1. Mamaeva T.A., Rubalskaya T.S., Zherdeva P.E., Metelskaya V.A., Toptygina A.P. Determination of the immune re-sponse type in measles patients of different ages from a high-incidence area. Rossiiskii immunologicheskii zhurnal, 2024, vol. 27, no. 1, pp. 49–58. DOI: 10.46235/1028-7221-16572-DOT (in Russian).
  2. Ershevskaya A.B., Ivanova A.A., Antropova G.A., Toyirov Y.A. Pertussis: aspects of pathogenesis and post-vaccination Immunity in children. Vestnik NovSU, 2024, no. 2 (136), pp. 247–255. DOI: 10.34680/2076-8052.2024.2(136).247-255 (in Russian).
  3. Niiazalieva M.S., Toygombaeva V.S., Djumalieva G.A., Aldjambaeva I.Sh. The condition of post-vaccination immunity to diphtheria and tetanus in population of the Republic of Kyrgyzstan. Problemy sotsial’noi gigieny, zdravookhraneniya i istorii meditsini, 2021, vol. 29, no. 4, pp. 988–991. DOI: 10.32687/0869-866X-2021-29-4-988-991 (in Russian).
  4. Dimitrieva M.A., Mikhailova A.S., Stepenova A.A., Anisimova T.A. The incidence of measles in Russia and abroad: causes and trends. Naukosfera, 2024, no. 5–1, pp. 94–97. DOI: 10.5281/zenodo.11188933 (in Russian).
  5. Shershneva N.N., Kolesnikov P.S., Samosadova P.V. Mishutkina Ya.V., Mardanly S.G. The relevance of serological monitoring of antitoxic immune to diphtheria. Poliklinika, 2022, no. 4, pp. 47–50 (in Russian).
  6. Grinchik P.R., Namazova-Baranova L.S., Fedoseenko M.V., Girina A.A., Kovalev S.V., Mazokha A.V., Makushina E.D., Malinina E.I. [et al.]. Comparative Analysis of Immunization and Immunization Coverage in Children of Russian Federation Federal Districts. Pediatricheskaya farmakologiya, 2022, vol. 19, no. 1, pp. 6–19. DOI: 10.15690/pf.v18i6.2351 (in Russian).
  7. Avramenko A.A., Isaeva M.A., Kushnir S.A., Sadovski K.A., Bocharova K.A. Aktual'nye problemy uvelicheniya zabolevaemost'yu kor'yu na territorii Rossiiskoi Federatsii i Belgorodskoi oblasti. Problemy i prognozy po razvitiyu ochagov vspyshki zabolevaniya [Current problems of increasing measles incidence in the Russian Federation and the Belgorod region. Problems and forecasts for the development of disease outbreaks]. Flagman nauki, 2023, vol. 11, no. 11, pp. 98–104. DOI: 10.37539/2949-1991.2023.11.11.019 (in Russian).
  8. Molochkova O.V., Kovalev O.B., Kosyreva M.A., Ilyina N.O., Shamsheva O.V., Getmanova E.N., Korsunsky A.A., Galeeva E.V., Guzhavina A.A. Characteristics of measles in children during the rise in incidence in 2019. Detskie infektsii, 2022, vol. 21, no. 4, pp. 27–31. DOI: 10.22627/2072-8107-2022-21-4-27-31 (in Russian).
  9. Dik D.A. Istoriya izucheniya kori, krasnukhi i epidemicheskogo parotita [History of studying measles, rubella and mumps]. Flagman nauki, 2023, no. 9 (9), pp. 140–142 (in Russian).
  10. Kurmaeva D.Yu., Afonin A.V., Rybalkin S.B., Melnikov V.L., Nikolskaya M.V. Epidemiological and clinical features of measles on the example of an outbreak in the Penza region. Sibirskii nauchnyi meditsinskii zhurnal, 2024, vol. 44, no. 4, pp. 168–173. DOI: 10.18699/SSMJ20240419 (in Russian).
  11. Tyukavkina S.Yu., Voronina N.A., Balakhnova V.V. Osnovnye faktory postvaktsinal'nogo immuniteta u privitykh AKDS-vaktsinoi [The main factors of post-vaccination immunity in those vaccinated with DPT vaccine]. Mikrobiologicheskie aspekty diagnostiki infektsionnykh zabolevanii: sbornik nauchno-prakticheskikh rabot IX Vserossiiskoi nauchno-prakticheskoi onlain-konferentsii. Rostov-on-Don, 2021, pp. 56–58 (in Russian).
  12. Nilova L.Yu., Orishak E.A., Fomenko V.O. Measles: global diagnostics programm and heard immunity. Problemy meditsinskoi mikologii, 2022, vol. 24, no. 2, pp. 108 (in Russian).
  13. Svetlichnaya S.V., Elagina L.A., Popovich L.D. Evaluation of the economic efficacy of vaccination against pertussis based on real-world data. Real'naya klinicheskaya praktika: dannye i dokazatel'stva, 2023, vol. 3, no. 1, pp. 9–19. DOI: 10.37489/2782-3784-myrwd-27 (in Russian).
  14. Alyabeva I.A., Kazakova V.S., Kosyakova K.G. Features of the spread of pertussis infection. Zdorov'e – osnova che-lovecheskogo potentsiala: problemy i puti ikh resheniya, 2023, vol. 18, no. 2, pp. 395–401 (in Russian).
  15. Basov A.A., Tsvirkun O.V., Gerasimova A.G., Zakoreeva A.K. The problem of pertussis in some geographic regions of the world. Infektsiya i immunitet, 2019, vol. 69, no. 2, pp. 354–362. DOI: 10.15789/2220-7619-2019-2-354-362 (in Russian).
  16. Fedorova I., Serhiyenka E., Rybak N., Matush L., Romanova O., Rybak V. Forgotten but Undecomputed Infection of the XXI Century – Diphtheria (Part 1). Klinicheskaya infektologiya i parazitologiya, 2023, vol. 12, no. 3, pp. 252–256. DOI: 10.34883/PI.2023.12.3.032 (in Russian).
  17. Serhiyenka E., Rybak N., Fedorova I., Matush L., Romanova O., Rybak V. Forgotten but Undecomputed Infection of the XXI Century – Diphtheria (Part 2). Klinicheskaya infektologiya i parazitologiya, 2023, vol. 12, no. 3, pp. 257–265. DOI: 10.34883/PI.2023.12.3.033 (in Russian).
  18. Kolesnikov P.S. ELISA and RPGA as methods of serological monitoring of diphtheria. Bakteriologiya, 2021, vol. 6, no. 1, pp. 48–53. DOI: 10.20953/2500-1027-2021-1-48-53 (in Russian).
  19. Markina S.S., Maksimova N.M., Petina V.S., Koshkina N.A., Fisenko V.A. Epidemicheskaya situatsiya po difterii v Rossii [Epidemic situation per diphtheria in Russia]. Moscow Research Institute of Epidemiology and Microbiology named after G.N. Gabrichevsky. Available at: http://www.gabrich.com/science/rdift.htm.html (October 09, 2024) (in Russian).
  20. Niyazalieva M.S., Toigombaeva V.S., Adambekov D.A., Aldzhambaeva I.Sh., Abdykerimova N.A., Kaipova U.T. Features of the epidemic process of measles, mumps and rubella at the present stage. Alatoo Academic Studies, 2023, no. 3, pp. 490–496. DOI: 10.17015/aas.2023.233.49 (in Russian).
  21. Bezrodnova S.M., Demurcheva I.V., Kravchenko O.O. Study of postvaccinal immunity to whooping cough in children with connective tissue dyslasia syndrome. Detskie infektsii, 2021, vol. 20, no. 1 (74), pp. 28–33. DOI: 10.22627/2072-8107-2021-20-1-28-33 (in Russian).
  22. Dmitrieva T.G., Nestereva M.E. An analysis of infectious morbidity in children in the Sakha Republic (Yakutia) from 2012 to 2021. Vestnik Severo-Vostochnogo federal'nogo universiteta im. M.K. Ammosova. Seriya «Meditsinskie nauki», 2023, no. 1 (30), pp. 37–46. DOI: 10.25587/SVFU.2023.30.1.001 (in Russian).
  23. Mikheeva E.M., Penkina N.I. Vaccine prophylaxis in children conceived with the help of assisted reproductive tech-nologies. Lechenie i profilaktika, 2023, vol. 13, no. 2, pp. 51–58 (in Russian).
  24. Ereshchenko A.A., Gusyakova O.A., Baldina O.A. Predicting the formation of post-vaccine measles humoral immunity in health care workers. Laboratornaya meditsina, 2023, vol. 14, no. 3–4, pp. 19–26. DOI: 10.58953/15621790_2023_14_3-4_19 (in Russian).
  25. Fridman I.V., Lybimova N.A., Goleva O.V., Konstantinova Yu.E., Kostik M.M. Safety of antibodies to measles, mumps, rubella and diphtheria in patients with juvenile idiopathic arthritis. Zhurnal infektologii, 2021, vol. 13, no. 2, pp. 44–52. DOI: 10.22625/2072-6732-2021-13-2-44-52 (in Russian).
  26. Shafalinov A.V., Rediako A.A., Ivanov D.V. Measles. Problem issues. Vestnik Vostochno-Sibirskoi otkrytoi akademii, 2024, no. 52 (52) (in Russian).
  27. Krieger E.A., Samodova O.V. Measles humoral immunity in health-care workers. Infektsiya i immunitet, 2021, vol. 11, no. 3, pp. 523–529. DOI: 10.15789/2220-7619-HIT-1452 (in Russian).
  28. Kryazhev D.A., Boev V.M., Kryazheva E.A. Vzaimosvyazi i prognosticheskie modeli faktorov sredy obitaniya, vliyayushchie na sostoyanie postvaktsinal'nogo immuniteta u naseleniya [Relationships and prognostic models of environmental factors influencing the state of post-vaccination immunity in the population]. Al'manakh molodoi nauki, 2017, no. 3, pp. 3–10 (in Russian).
  29. Shvetsova A.A., Kryazheva E.A. Vzaimosvyaz' antropogennogo zagryazneniya so snizheniem postvaktsinal'nogo immuniteta u naseleniya Orenburgskoi oblasti [The relationship of anthropogenic pollution with a decrease in post-vaccination immunity among the population of the Orenburg region]. Materialy XII s"ezda Vserossiiskogo nauchno-prakticheskogo ob-shchestva epidemiologov, mikrobiologov i parazitologov. In: A.Yu. Popova, V.G. Akimkin eds. Moscow, 2022, pp. 533–534 (in Russian).
  30. Kryazhev D.A., Boev M.V., Tulina L.M., Neplokhov A.A., Boev V.M. Comprehensive assessment of environmental factors and postvaccinal immune state. Gigiena i sanitariya, 2016, vol. 95, no. 3, pp. 229–232. DOI: 10.18821/0016-9900-2016-95-3-229-232 (in Russian).
  31. Ilina S.V., Savilov E.D. Technogenic Environmental Pollution and the Effectiveness of Vaccination in Children's Population. Epidemiologiya i vaktsinoprofilaktika, 2009, vol. 47, no. 4, pp. 57–62 (in Russian).
  32. Akhmadiev G.M. The dependence of the extinction of immunoglobulins in the blood of mammalian offspring by state habitat. Aktual'nye issledovaniya gumanitarnykh, estestvennykh, obshchestvennykh nauk: materialy VIII Vserossiiskoi s mezhdu-narodnym uchastiem nauchno-prakticheskoi konferentsii. Novosibirsk, OOO “TsSRNI” Publ., 2016, pp. 8–15 (in Russian).
  33. Pospelova S.V., Horovits E.S., Krivtsov A.V., Dolgikh O.V. Study of protective anti-bacterial mechanisms in children living in the conditions of exposure to emissions of the enterprise of black metallurgy. Laboratornaya sluzhba, 2021, vol. 10, no. 2, pp. 22–27. DOI: 10.17116/labs20211002122 (in Russian).
  34. Dolgikh O.V., Krivtsov A.V., Bubnova O.A., Otavina E.A., Bezruchenko N.V., Kolegova A.A., Mazunina A.A., Guselnikov M.A. Features of fixing the genetic polymorphism in dyads “mother – child” in the conditions of aerogenous exposure to metals. Gigiena i sanitariya, 2017, vol. 96, no. 1, pp. 26–29. DOI: 10.47470/0016-9900-2017-96-1-26-29 (in Russian).
  35. Starkova K.G., Dolgikh O.V., Kazakova O.A. Features of the immune status of middle and high school students in conditions of high blood content of a number of exogenous chemical impurities. Gigiena i sanitariya, 2021, vol. 100, no. 5, pp. 501–506. DOI: 10.47470/0016-9900-2021-100-5-501-506 (in Russian).
  36. Alikina I.N. Assessment of cell-mediated immunity in workers employed in underground chrome ore mining. Rossiiskii immunologicheskii zhurnal, 2019, vol. 22, no. 3, pp. 1089–1092. DOI: 10.31857/S102872210007231-9 (in Russian).
  37. Kostinov M.P., Prutskova E.V., Cherdantsev A.P., Feiskhanova G.R., Kostinov A.M., Vlasenko A.E., Polishchuk V.B. Safety of pertussis vaccines for adolescents. Zhurnal infektologii, 2020, vol. 12, no. 4, pp. 29–36. DOI: 10.22625/2072-6732-2020-12-4-29-36 (in Russian).
Received: 
12.11.2024
Approved: 
02.12.2024
Accepted for publication: 
19.12.2024

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