Criteria eligible for establishing reference concentrations of adverse chemicals under chronic inhalation exposure by extrapolation of the existing parameters

UDC: 
613; 614
DOI: 
10.21668/health.risk/2024.4.03.eng
Authors: 

P.Z. Shur, А.А. Khasanova

Organization: 

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation

Abstract: 

Some chemicals emitted into ambient air do not have eligible parameters for assessing associated non-carcinogenic health risks under chronic inhalation exposure. Therefore, it is relevant to extend the list of reference concentrations (RfC), among other things, to perform health risk assessment within implementation of the Clean Air Federal Project. The same reference concentrations and critical organs and systems can be fixed for different compounds of the same chemical in accordance with the Guide R 2.1.10.3968-23. This makes it possible to establish non-identified RfC values by extrapolating the existing parameters from a donor to an acceptor.

The article suggests eligible criteria for establishing reference concentrations under chronic inhalation exposure by extrapolation of the existing parameters. They include identity of chemicals per selective toxicity towards target organs and / or systems upon chronic exposure, identical critical organs and systems, identical specific effects (sensitizing and mutagenic effects and reproductive toxicity) and similar physiochemical properties.

Use of extrapolation criteria allowed suggesting RfC of cadmium oxide equal to 2•10-5 mg/m3; cadmium was employed as a donor for extrapolation. Verification results confirmed that the conventionally substantiated RfC value was consistent with the value obtained by extrapolation. At the same time, we found that it was unacceptable to establish RfC of cadmium sulfate by extrapolation from cadmium since the former chemical was more toxic in accordance with the suggested criteria as regards its mutagenic effects and reproductive toxicity. In addition, its physiochemical properties were different from those of cadmium.

Keywords: 
parameters for health risk assessment, risk assessment, reference concentration, non-carcinogenic risk, extrapolation, extrapolation criteria, cadmium
Shur P.Z., Khasanova А.А. Criteria eligible for establishing reference concentrations of adverse chemicals under chronic inhalation exposure by extrapolation of the existing parameters. Health Risk Analysis, 2024, no. 4, pp. 27–36. DOI: 10.21668/health.risk/2024.4.03.eng
References: 
  1. Novikov S.M., Shashina T.A., Khamidulina Kh.Kh., Skvortsova N.S., Unguryanu T.N., Ivanova S.V. Current prob-lems in the system of state regulation of chemical safety. Gigiena i sanitariya, 2013, no. 4, pp. 93–98 (in Russian).
  2. Zaytseva N.V., Popova A.Yu., May I.V., Shur P.Z. Methods and technologies of health risk analysis in the system of the state management under assurance of the sanitation and epidemiological welfare of population. Gigiena i sanitariya, 2015, vol. 94, no. 2, pp. 93–98 (in Russian).
  3. Onishchenko G.G., Zaitseva N.V., Popova A.Yu. [et al.]. Analiz riska zdorov'yu v strategii gosudarstvennogo sotsi-al'no-ekonomicheskogo razvitiya [Health risk analysis in the strategy of state social and economic development]: monograph, 2nd ed., revised and supplemented. In: G.G. Onishchenko, N.V. Zaitseva eds. Moscow, Perm, Perm National Research Polytechnic University Publ., 2024, 1048 p. (in Russian).
  4. Zorina I.G., Makarova V.V. Social and hygienic monitoring as the basis of а control in the control and supervisory ac-tivities of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Gigiena i sanitariya, 2020, vol. 99, no. 1, pp. 13–19 (in Russian).
  5. Shur P.Z., Zaitseva N.V., Khasanova A.A., Chetverkina K.V., Kostarev V.G. Improvement of quantitative indicators for assessing non-carcinogenic health risks under chronic inhalation exposure to a chemical. Gigiena i sanitariya, 2022, vol. 101, no. 11, pp. 1412–1418 (in Russian).
  6. Belyaev E.N., Fokin M.V, Novikov S.M., Prusakov V.M., Shashina T.A., Shayakhmetov S.F. Actual problems of im-proving the assessment of health risk for assurance of the sanitary and epidemiological well-being. Gigiena i sanitariya, 2013, vol. 92, no. 5, pp. 53–55 (in Russian).
  7. Nieto-Draghi C., Fayet G., Creton B., Rozanska X., Rotureau P., de Hemptinne J.-C., Ungerer P., Rousseau B., Adamo C. A general guidebook for the theoretical prediction of physicochemical properties of chemicals for regulatory purposes. Chem. Rev., 2015, vol. 115, no. 24, pp. 13093–13164.
  8. Katritzky A.R., Kuanar M., Slavov S., Hall D., Karelson M., Kahn I., Dobchev D.A. ChemInform abstract: quantitative correlation of physical and chemical properties with chemical structure: utility for prediction. Chem. Rev., 2010, vol. 110, no. 10, pp. 5714–5789.
  9. Globally Harmonized System of Classification and Labelling of Chemicals (GHS Rev. 10, 2023). United Nations, 2023, 592 p.
  10. U.S. EPA. A Review of the Reference Dose and Reference Concentration Processes: Final report (EPA/630/P-02/002F). U.S. Environmental Protection Agency, Risk Assessment Forum. Washington, DC, USA, 2002, 192 p.
  11. Chapter 5. Dose-response assessment and derivation of health-based guidance values. In book: Environmental Health Criteria 240: Principles for risk assessment of chemicals in food. Geneva, World Health Organization, 2009, 64 р.
  12. Balali-Mood M., Naseri K., Tahergorabi Z., Khazdair M.R., Sadeghi M. Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front. Pharmacol., 2021, vol. 12, pp. 643972.
  13. Charkiewicz A.E., Omeljaniuk W.J., Nowak K., Garley M., Nikliński J. Cadmium toxicity and health effects-a brief summary. Molecules, 2023, vol. 28, no. 18, pp. 6620.
  14. Sun J., Deng Y.-P., Xu J., Zhu F.-M., He Q.-Y., Tang M.-M., Liu Y., Yang J. [et al.]. Association of blood cadmium concentration with chronic obstructive pulmonary disease progression: a prospective cohort study. Respir. Res., 2024, vol. 25, no. 1, pp. 91. DOI: 10.1186/s12931-024-02726-0
  15. Palus J., Rydzynski K., Dziubaltowska E., Wyszynska K., Natarajan A.T., Nilsson R. Genotoxic effects of occupational exposure to lead and cadmium. Mutat. Res., 2003, vol. 540, no. 1, pp. 19–28. DOI: 10.1016/s1383-5718(03)00167-0
  16. Abrahim K.S., Abdel-Gawad N.B., Mahmoud A.M., El-Gowaily M.M., Emara A.M., Hwaihy M.M. Genotoxic effect of occupational exposure to cadmium. Toxicol. Ind. Health, 2011, vol. 27, no. 2, pp. 173–179. DOI: 10.1177/0748233710383743
  17. Robbiano L., Baroni D., Novello L., Brambilla G. Correlation between induction of DNA fragmentation in lung cells from rats and humans and carcinogenic activity. Mutat. Res., 2006, vol. 605, no. 1–2, pp. 94–102. DOI: 10.1016/j.mrgentox.2006.03.001
  18. Akinloye O., Arowojolu A.O., Shittu O.B., Anetor J.I. Cadmium toxicity: a possible cause of male infertility in Nigeria. Reprod. Biol., 2006, vol. 6, no. 1, pp. 17–30.
  19. Telisman S., Cvitković P., Jurasović J., Pizent A., Gavella M., Rocić B. Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men. Environ. Health Perspect., 2000, vol. 108, no. 1, pp. 45–53. DOI: 10.1289/ehp.0010845
  20. Järup L., Hellström L., Alfvén T., Carlsson M.D., Grubb A., Persson B., Pettersson C., Spång G. [et al.]. Low level exposure to cadmium and early kidney damage: The OSCAR study. Occup. Environ. Med., 2000, vol. 57, no. 10, pp. 668–672. DOI: 10.1136/oem.57.10.668
  21. Suwazono Y., Sand S., Vahter M., Filipsson A.F., Skerfving S., Lidfeldt J., Akesson A. Benchmark dose for cad-mium-induced renal effects in humans. Environ. Health Perspect., 2006, vol. 114, no. 7, pp. 1072–1076. DOI: 10.1289/ehp.9028
Received: 
31.10.2024
Approved: 
11.11.2024
Accepted for publication: 
17.12.2024

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