Structure of some diseases and health risks for people residing in surrounding areas previously contained herbicides/dioxin

UDC: 
614.7
DOI: 
10.21668/health.risk/2024.2.05.eng
Authors: 

Trinh Khac Sau, Le Van Quang

Organization: 

Institute of Tropical Medicine, Joint Vietnam-Russia Tropical Science and Technology Research Center, 63 Nguyen Van Huyen St., Cau Giay district, Hanoi, Vietnam

Abstract: 

During the war in Vietnam from 1961–1971, the US military used and sprayed nearly 80 million liters of herbicides in South Vietnam. Bien Hoa, Da Nang, and Phu Cat airports are herbicides repositories and hot spots for dioxin residues. The aim of this study was to examine the structure of some diseases and health risks of 1039 subjects residing around Da Nang, Bien Hoa, and Phu Cat airports (the ∑SG – study group) and 400 subjects residing in Son Tra district in Da Nang city – far from Da Nang airport (the ST – control group).

The analysis results show that the prevalence of some relevant diseases related to herbicides/dioxin in the ∑SG group has a high percentage such as hypertension: 23.0–33.6 % (mean: 29.6 %), diabetes: 3.50–13.0 % (mean: 9.62 %) and other diseases: stomach: 23.6–37 % (mean: 26.3 %), joints: 34.6–40.3 % (mean: 37.8 %), ear-nose and throat: 9.5–17.4 % (mean: 15.5 %), kidney-urinary system: 4.5–7.2 % (mean: 6 %). These values were 1.5 to 9 times higher in the ∑SG group than in the ST group. The subjects who resided and worked around airports had elevated risks of the foregoing diseases. The structure of these diseases in both the ∑SG and the ST groups depends on sex and age, but the decisive factor depends on herbicides/dioxin exposure status. Thus, exposure to herbicides/dioxin has changed the disease pattern and increased some aspects of disease in people residing near areas where herbicides/dioxin was previously stored.

Keywords: 
herbicides, dioxin, hot spot, diseases, health risks, Da Nang, Bien Hoa, Phu Cat
Trinh Khac Sau, Le Van Quang. Structure of some diseases and health risks for people residing in surrounding areas pre-viously contained herbicides/dioxin. Health Risk Analysis, 2024, no. 2, pp. 53–62. DOI: 10.21668/health.risk/2024.2.05.eng
References: 
  1. Stellman J.M., Stellman S.D., Christian R., Weber T., Tomasallo C. The extent and patterns of usage of Agent Orange and other herbicides in Vietnam. Nature, 2003, vol. 422, pp. 681–687. DOI: 10.1038/nature01537
  2. Young A.L. The History, Use, Disposition and Environmental Fate of Agent Orange. NY, Springer New York Publ., 2009, 339 p. DOI: 10.1007/978-0-387-87486-9
  3. Pham D.T., Nguyen H.M., Boivin T.G., Zajacova A., Huzurbazar S.V., Bergman H.L. Predictors for dioxin accumulation in residents living in Da Nang and Bien Hoa, Vietnam, many years after Agent Orange use. Chemosphere, 2015, vol. 118, pp. 277–283. DOI: 10.1016/j.chemosphere.2014.09.064
  4. Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Tenth Biennial Update), Board on the Health of Select Populations, Institute of Medicine, National Academies of Sciences, Engineering, and Medicine. Veterans and Agent Orange: Update 2014. Washington, DC, The National Academies Press Publ., 2016, 1114 p. DOI: 10.17226/21845
  5. Manh H.D., Kido T., Takasuga T., Yamashita M., Giang L.M., Nakagawa H. The Relationship of Dioxin Levels in Serum of 9-Year-Old Vietnamese Children and Their Mothers' Breast Milk. Toxics, 2022, vol. 10, no. 4, pp. 155. DOI: 10.3390/toxics10040155
  6. Nishijo M. Dioxin and Dioxin-like Compounds and Human Health. Toxics, 2023, vol. 11, no. 6, pp. 512. DOI: 10.3390/toxics11060512
  7. Nishijo M., Tai P.T., Nakagawa H., Maruzeni S., Anh N.T.N., Luong H.V., Anh T.H., Honda R. [et al.]. Impact of perinatal dioxin exposure on infant growth: a cross-sectional and longitudinal studies in dioxin-contaminated areas in Vietnam. PLoS One, 2012, vol. 7, no. 7, pp. e40273. DOI: 10.1371/journal.pone.0040273
  8. Nishijo M., Pham T.T., Nguyen A.T.N., Tran N.N., Nakagawa H., Hoang L.V., Tran A.H., Morikawa Y. [et al.]. 2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam. Mol. Psychiatry, 2014, vol. 19, no. 11, pp. 1220–1226. DOI: 10.1038/mp.2014.18
  9. Tran N.N., Pham T.T., Ozawa K., Nishijo M., Nguyen A.T.N., Tran T.Q., Hoang L.V., Tran A.H. [et al.]. Impacts of Perinatal Dioxin Exposure on Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year Follow-Up. PLoS One, 2016, vol. 11, no. 1, pp. e0147655. DOI: 10.1371/journal.pone.0147655
  10. Dwernychuk L.W. Dioxin hot spots in Vietnam. Chemosphere, 2005, vol. 60, no. 7, pp. 998–999. DOI: 10.1016/j.chemosphere.2005.01.052
  11. Tai P.T., Nishijo M., Kido T., Nakagawa H., Maruzeni S., Naganuma R., Anh N.T.N., Morikawa Y. [et al.]. Dioxin concentrations in breast milk of Vietnamese nursing mothers: a survey four decades after the herbicide spraying. Environ. Sci. Technol., 2011, vol. 45, no. 15, pp. 6625–6632. DOI: 10.1021/es201666d
  12. Tuyet-Hanh T.T., Minh N.H., Vu-Anh L., Dunne M., Toms L.-M., Tenkate T., Thi M.-H.N., Harden F. Environmental health risk assessment of dioxin in foods at the two most severe dioxin hot spots in Vietnam. Int. J. Hyg. Environ. Health, 2015, vol. 218, no. 5, pp. 471–478. DOI: 10.1016/j.ijheh.2015.03.014
  13. World Health Organization. Assessment of the health risks of dioxin: re-evaluation of the Tolerable Daily Intake (TDI). Executive summary. Geneva, WHO European Centre for Environment and Health, International Programme on Chemical Safety, 1998, 28 p.
  14. Sau T.K., Truong N.X., Hanh T.T.T., Le Hung B., Thang N.D., Le Lan Anh T. Ambient air monitoring around the dioxin remediation site in Da Nang, Vietnam, using passive air samplers. Environ. Monit. Assess., 2021, vol. 193, no. 7, pp. 434. DOI: 10.1007/s10661-021-09223-7
  15. Choi H.M., Kim H.C., Kang D.R. Sex differences in hypertension prevalence and control: Analysis of the 2010–2014 Korea National Health and Nutrition Examination Survey. PLoS One, 2017, vol. 12, no. 5, pp. e0178334. DOI: 10.1371/journal.pone.0178334
  16. Díaz A., Beleña Á., Zueco J. The Role of Age and Gender in Perceived Vulnerability to Infectious Diseases. Int. J. Environ. Res. Public Health, 2020, vol. 17, no. 2, pp. 485. DOI: 10.3390/ijerph17020485
  17. Nordström A., Hadrévi J., Olsson T., Franks P.W., Nordström P. Higher Prevalence of Type 2 Diabetes in Men Than in Women Is Associated With Differences in Visceral Fat Mass. J. Clin. Endocrinol. Metab., 2016, vol. 101, no. 10, pp. 3740–3746. DOI: 10.1210/jc.2016-1915
  18. The American people’s dioxin report: technical support document. Falls Church, VA, Center for Health Environment and Justice, 1999.
  19. Announcing the results of the national investigation of risk factors for non-communicable disease in 2015. Vietnam General Department of Preventive Medicine, 2015. Available at: https://vncdc.gov.vn/cong-bo-ket-qua-dieu-tra-quoc-gia-yeu-to-nguy-co-be... (February 09, 2024).
  20. National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Population Health and Public Health Practice, Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Eleventh Biennial Update). Veterans and Agent Orange: Update 11 (2018). Washington, DC, National Academies Press Publ., 2018. DOI: 10.17226/25137
Received: 
14.11.2023
Approved: 
31.05.2024
Accepted for publication: 
20.06.2024

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