Role of cellular immunity in malignant tumors development in individuals chronically ex-posed to ionising radiation

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UDC: 
612.017.11: 612.014.482
DOI: 
10.21668/health.risk/2024.1.17.eng
Authors: 

V.L. Rybkina, D.S. Oslina, T.V. Azizova, E.N. Kirillova, V.S. Makeeva

Organization: 

Southern Urals Biophysics Institute, 19 Ozerskoe shosse, Ozersk, 456780, Russian Federation

Abstract: 

Some long-term effects of radiation could be related to changes in the immune system resulting from radiation exposure. Immunity disorders caused by radiation can influence carcinogenesis.

Cellular immunity factors were investigated in peripheral blood of workers chronically exposed to occupational combined radiation (external gamma-rays and internal alpha-particles), with malignant
neoplasms diagnosed after blood samples were taken or without them, and in the control group.

The aim of this study was examine effects of radiation on the cellular immunity status in individuals chronically exposed to ionizing radiation who had malignant neoplasms developed after blood sampling.

The relative and absolute number of lymphocyte subpopulations (total T-cells, T-helpers, T-cytotoxic, total B-cells, NK-cells, NKT-cells and activated T-cells) was detected by flow cytofluorometry.
The absolute number of T-cells was significantly reduced in workers chronically exposed to occupational combined irradiation, with or without malignancies, compared to the control, which may contribute to tumor progression at an early stage of its onset. At the same time, workers without malignancies had a significant increase in the relative number of T-cytotoxic lymphocytes, which may be a factor preventing tumor development. A significant increase in the relative number of natural killer cells (NK cells) was detected in individuals with malignant neoplasms chronically exposed to occupational combined irradiation, compared with the control, which may indicate enhanced antitumor defense that developed in response to exposure to tumor antigens. In addition, a significant decrease in the absolute and relative number of T- and B-lymphocytes was found in the group of workers with malignant neoplasm, compared with the control. A significant increase in the relative number of T-helpers was found in both groups of workers. Since the role of T-helpers in the antitumor response is ambiguous, additional research on types of T-helpers is planned to clarify the results of the present study.

Keywords: 
occupational exposure, ionizing radiation, malignant neoplasms, innate immunity, adaptive immunity, antitumor immunity, T- and B-lymphocytes, T-helpers
Rybkina V.L., Oslina D.S., Azizova T.V., Kirillova E.N., Makeeva V.S. Role of cellular immunity in malignant tumors development in individuals chronically exposed to ionising radiation. Health Risk Analysis, 2024, no. 1, pp. 169–177. DOI: 10.21668/health.risk/2024.1.17.eng
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Received: 
05.11.2023
Approved: 
13.03.2024
Accepted for publication: 
20.03.2024

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