Development of the risk analysis methodology given the current safety challenges for public health in the Russian Federation: Vital issues and prospects

View or download the full article: 
PDF icon health-risk-analysis-2023-4-1.pdf
UDC: 
613
DOI: 
10.21668/health.risk/2023.4.01.eng
Authors: 

G.G. Onishchenko

Organization: 

1Russian Academy of Education, 8 Pogodinskaya St., Moscow, 119121, Russian Federation
2I.M. Sechenov First Moscow State Medical University, 8 Trubetskaya St., build. 2, Moscow, 119048, Russian Federation
3Medical Sciences Department, Russian Academy of Sciences, 14 Leninskii Av., Moscow, 119071, Russian Federation

Abstract: 

The contemporary socioeconomic situation creates multiple safety challenges in the Russian Federation including public health safety. These challenges cannot be ignored when formulating strategic tasks of health risk analysis within predictions of the socioeconomic development of the Russian Federation for the period up to 2030. Targeted development of the risk analysis methodology in the Russian Federation has provided solid grounds for successful solution of primary tasks related to providing sanitary-epidemiological wellbeing of the country population. It has created a platform for further improvement of activities performed by the Rospotrebnadzor in various spheres. This includes development and greater detailing of results obtained by examining how health risks occur under exposure to heterogeneous environmental factors and work-related ones considering their combined effects. Another significant trend is proactive development of methods for assessing and managing health risks associated with potentially hazardous factors of new technologies and products (nanotechnologies, new foods, etc.).

Several fundamental aspects of risk analysis can be considered vital at the moment. This includes investigating mechanisms of risk occurrence; establishing regularities of risks of negative health outcomes with various severities under ongoing integration of body systems dysfunctions and considering capabilities of the body to recover its proper functioning and its adaptive resources; finding solutions to an issue associated with assessing additive properties of effects produced by risk factors including heterogeneous ones. Fundamental aspects of health risks analysis development are closely connected with an issue associated with formulating fundamentals of an information platform eligible for this methodology. It is impossible to achieve any development in investigating mechanisms of health risks occurrence under exposure to heterogeneous environmental factors and work-related ones without applying up-to-date investigation techniques, digital ones included.

The existing safety challenges for public health in the Russian Federation include the necessity to protect public health in order to extend a period of economic activity of the population and to develop labor and economic potential of the country; high levels of adverse impacts on the public health exerted by chemical, physical, and biological environmental factors; insufficient ‘digital maturity’ of methods employed to predict threats and provide sanitary-epidemiological wellbeing of the population. Given all the aforementioned, it seems advisable to outline the following promising trends in the development of the health risk analysis methodology: developing the fundamentals the methodology is based on; enlarging practical use of health risk assessment results in everyday activities of the Rospotrebnadzor; creating an information platform and digitalizing health risk analysis; developing a methodology for substantiating effective preventive programs aimed at health risk management.

Keywords: 
health risk, safety, risk analysis methodology, information platform, digitalization
Onishchenko G.G. Development of the risk analysis methodology given the current safety challenges for public health in the Russian Federation: vital issues and prospects. Health Risk Analysis, 2023, no. 4, pp. 4–18. DOI: 10.21668/health.risk/2023.4.01.eng
References: 
  1. Popova A.Yu., Zaitseva N.V., Onishchenko G.G., Kleyn S.V., Glukhikh M.V., Kamaltdinov M.R. Sanitary-epidemiologic determinants and potential for growth in life expectancy of the population in the Russian Federation taking into account regional differentiation. Health Risk Analysis, 2020, no. 1, pp. 4–17. DOI: 10.21668/health.risk/2020.1.01.eng
  2. Zaitseva N.V., Onishchenko G.G., May I.V., Shur P.Z. Development of methodology for health risk assessment within the public administration of population sanitary and epidemiological welfare. Health Risk Analysis, 2022, no. 3, pp. 4–20. DOI: 10.21668/health.risk/2022.3.01.eng
  3. Popova A.Yu., Onishchenko G.G., Rakitskii V.N., Kuzmin S.V., Kuchma V.R. Hygiene in supporting scientific and technological development of the country and sanitary and epidemiological welfare of the population (to the 130th anniversary of the Federal Scientific Centre of Hygiene named after F.F. Erisman). Gigiena i sanitariya, 2021, vol. 100, no. 9, pp. 882–889. DOI: 10.47470/0016-9900-2021-100-9-882-889 (in Russian).
  4. Shur P.Z., Zaitseva N.V., Khasanova A.A., Chetverkina K.V., Kostarev V.G. Improvement of quantitative indicators for assessing non-carcinogenic health risks under chronic inhalation exposure to a chemical. Gigiena i sanitariya, 2022, vol. 101, no. 11, pp. 1412–1418. DOI: 10.47470/0016-9900-2022-101-11-1412-1418 (in Russian).
  5. Trusov P.V., Zaitseva N.V., Kamaltdinov M.R. A multiphase flow in the antroduodenal portion of the gastrointestinal tract: a mathematical model. Comput. Math. Methods Med., 2016, vol. 2016, pp. 5164029. DOI: 10.1155/2016/5164029
  6. Kamaltdinov M., Zaitseva N., Trusov P. A mathematical model of the multiphase flow in the antroduodenum: consideration of the digestive enzymes and regulation processes. Series on biomechanics, 2018, vol. 32, no. 3, pp. 36–42.
  7. Trusov P.V., Zaitseva N.V., Chigvintsev V.M., Lanin D.V. Regulation of organism's antiviral immune response: mathematical model, qualitative analysis, results. Matematicheskaya biologiya i bioinformatika, 2018, vol. 13, no. 2, pp. 402–425. DOI: 10.17537/2018.13.402 (in Russian).
  8. Zaitseva N.V., Shur P.Z., May I.V., Kiryanov D.A. On the question of the application of the prediction of the evolution of health risk in hygienic assessments. Gigiena i sanitariya, 2016, vol. 95, no. 1, pp. 106–112. DOI: 10.18821/0016-9900-2016-95-1-106-112 (in Russian).
  9. Trusov P.V., Zaitseva N.V., Kiryanov D.A., Kamaltdinov M.R., Cinker M.Ju., Chigvintsev V.M., Lanin D.V. A mathematical model for evolution of human functional disorders influenced by environment factors. Matematicheskaya biologiya i bioinformatika, 2012, vol. 7, no. 2, pp. 589–610 (in Russian).
  10. Mai I.V., Zinker M.Y., Chigvintsev V.M., Koshurnikov D.N. Approach to health risk assessment under noise impact. ZNiSO, 2011, no. 10 (223), pp. 10–12 (in Russian).
  11. Trusov P.V., Zaitseva N.V., Tsinker M.Yu. Modeling of human breath: conceptual and mathematical statements. Matematicheskaya biologiya i bioinformatika, 2016, vol. 11, no. 1, pp. 64–80. DOI: 10.17537/2016.11.64 (in Russian).
  12. Trusov P.V., Zaitseva N.V., Tsinker M.Yu. On modeling of airflow in human lungs: constitutive relations to describe deformation of porous medium. Vestnik Permskogo natsional'nogo issledovatel'skogo politekhnicheskogo universiteta. Mekhanika, 2020, no. 4, pp. 165–174. DOI: 10.15593/perm.mech/2020.4.14 (in Russian).
  13. Angurets A.V. Klassifikatsiya riskov pri ispol'zovanii GMO [Classification of risks when using GMOs]. Fiziologiya transgennogo rasteniya i problemy biobezopasnosti: sb. tezisov konf., Moscow, 2004 (in Russian).
  14. Muller B.P., Zumdick A., Schuphan I., Schmidt B. Metabolism of the herbicide glufosinate-ammo¬nium in plant cell cultures of transgenic (rhizomania-resistant) and non-transgenic sugarbeet (Beta vulgaris), carrot (Daucus carota), purple foxglove (Digitalis purpurea) and thorn apple (Datura stramonium). Pest. Manag. Sci., 2001, vol. 57, no. 1, pp. 46–56. DOI: 10.1002/1526-4998(200101)57:13.0.CO;2-1
  15. Kuznetsov Vl.V. Vozmozhnye biologicheskie riski pri ispol'zovanii geneticheski modifitsirovannyh sel'skokhozyaistvennyh kul'tur [Possible biological risks when using genetically modified crops]. Vestnik DVO RAN, 2005, no. 3, pp. 40–54 (in Russian).
  16. Domingo J.L., Giné Bordonaba J. A literature review on the safety assessment of genetically modified plants. Environ. Int., 2011, vol. 37, no. 4, pp. 734–742. DOI: 10.1016/j.envint.2011.01.003
  17. Tyshko N.V., Sadykova E.O., Shestakova S.I., Aksyuk I.N. Novel food sources: from GMO to the broadening of Russia's bioresource base. Voprosy pitaniya, 2020, vol. 89, no. 4, pp. 100–109. DOI: 10.24411/0042-8833-2020-10046 (in Russian).
  18. Tutelyan V.A., Tyshko N.V., Sadykova E.O. Food derived from genetically modified animals: formation of safety assessment system and new approaches to toxicological research. Toxicology Letters, 2019, vol. 314, suppl. 1, pp. s241–s242.
  19. European Commission Directorate – General for Research and Innovation. New challenges for agricultural research: climate change, food security, rural development, agricultural knowledge systems. European Commission, 2009. Available at: https://op.europa.eu/mt/publication-detail/-/publication/83dfc16f-18b8-4... (October 16, 2023).
  20. Domingo J.L. Health risks of GM foods: many opinions but few data. Science, 2000, vol. 288, no. 5472, pp. 1748–1749. DOI: 10.1126/science.288.5472.1748
  21. GMO: Kontrol' nad obshchestvom ili obshchestvennyi kontrol'? [GMO: Control over society or public control?]. In: V.B. Kopeikina ed. Moscow, GEOS, 2005, 198 p. (in Russian).
  22. Tyshko N.V. Control over genetically-modified sources of plant origin in food: scientific basis and methodical maintenance. Voprosy pitaniya, 2017, vol. 86, no. 5, pp. 29–33 (in Russian).
  23. Gmoshinskiy I.V., Shipelin V.A., Khotimchenko S.A. Microplastics in food: origin, properties and possible risks. Meditsina truda i ekologiya cheloveka, 2022, no. 2 (30), pp. 224–242. DOI: 10.24412/2411-3794-2022-10216 (in Russian).
  24. Gmoshinski I.V., Shipelin V.A., Khotimchenko S.A. Nanocelluloses: hazard characteristics and possible risks (literature review). Gigiena i sanitariya, 2023, vol. 102, no. 2, pp. 181–190. DOI: 10.47470/0016-9900-2023-102-2-181-190 (in Russian).
  25. Zaitseva N.V., Zemlyanova M.A., Stepankov M.S., Ignatova A.M., Nikolaeva A.E. Study of features of bioaccumulation and pathomorphological changes in tissues of rat organs after a single inhalation exposure to molybdenum (VI) oxide nanoparticles in comparison with a microdisperse analogue. Gigiena i sanitariya, 2022, vol. 101, no. 6, pp. 622–627. DOI: 10.47470/0016-9900-2022-101-6-622-627 (in Russian).
  26. Zemlyanova M.A., Zaitseva N.V., Stepankov M.S., Ignatova A.M. Evaluation potential hazard of molybdenum (VI) oxide nanoparticles for human health. Ekologiya cheloveka, 2022, no. 8, pp. 563–575. DOI: 10.17816/humeco108248 (in Russian).
  27. Zemlyanova M.A., Zaitseva N.V., Stepankov M.S. Peculiarities of toxic effects produced by aluminum oxide nano and microparticles under multiple inhalation exposure. Gigiena i sanitariya, 2023, vol. 102, no. 5, pp. 502–508. DOI: 10.47470/0016-9900-2023-102-5-502-508 (in Russian).
  28. Izmerov N.F. Global plan of actions on workers’ health preservation for 2008–2017: ways and prospects of realization. Meditsina truda i promyshlennaya ekologiya, 2008, no. 6, pp. 1–9 (in Russian).
  29. Materialy XII Vserossiiskogo kongressa «Professiya i zdorov'e» i V Vserossiiskogo s’’ezda vrachei-profpatologov: sbornik materialov, posvyashchennykh 90-letiyu FGBU «NII meditsiny truda» RAMN [Materials of the XII All-Russian Congress “Occupation and Health” and the V All-Russian Congress of Occupational Pathologists: a collection of materials dedicated to the 90th anniversary of the Federal State Budgetary Institution “Research Institute of Occupational Medicine” of the Russian Academy of Medical Sciences]. In: N.F. Izmerov ed. Moscow, Reinfor Publ., 2013, 548 p. (in Russian).
  30. Onishchenko G.G. Working conditions and occupational morbidity in workers of the Russian Federation. Gigiena i sanitariya, 2009, no. 1, pp. 10 (in Russian).
  31. Mukhin N.N., Izmerov N.F., Sorokina N.S. Professional'naya patologiya segodnya. Problemy i resheniya [Occupational pathology today. Problems and solutions]. Materialy XII Vserossiiskogo kongressa «Professiya i zdorov'e» i V Vserossiiskogo s’’ezda vrachei-profpatologov. Moscow, November 27–30, 2013, pp. 49–61 (in Russian).
  32. Bezrukova G.A., Novikova T.A., Shalashova M.L., Raikin S.S. Professional risk of developing diseases of the peripheral nervous system in tractor drivers – machine operators of agricultural production. Health Risk Analysis, 2015, no. 3, pp. 47–54. DOI: 10.21668/health.risk/2015.3.07.eng
  33. Shlyapnikov D.M., Shur P.Z., Alexeev V.B., Uhabov V.M., Novoselov V.G., Perevalov A.Y. New potential of MTHFR gene variations application as an individual sensitivity marker in evaluation of occupational risk of arterial hypertension under exposure to nose. Meditsina truda i promyshlennaya ekologiya, 2016, no. 8, pp. 6–10 (in Russian).
  34. Novik I.I., Pisarik V.M., Rostovtsev V.N. Markery predraspolozhennosti k ishemicheskoi bolezni serdtsa i arterial'noi gipertenzii [Markers of predisposition to coronary heart disease and arterial hypertension]. Zdravookhranenie, 1999, no. 4, pp. 38–41 (in Russian).
  35. Alekseev V.B., Shur P.Z., Lir D.N., Fokin V.A. Methodical approaches to for quantitative assessment of health risk associated with the labour process strength. Gigiena i sanitariya, 2021, vol. 100, no. 10, pp. 1171–1178. DOI: 10.47470/0016-9900-2021-100-10-1171-1178 (in Russian).
  36. Luzhetsky K.P., Ustinova O.Yu., Shur P.Z., Kiryanov D.A., Dolgikh O.V., Chigvintsev V.M., Perevalov A.Y. Development of lipids and carbohydrates metabolism disorders caused by drinkable water with high content of chlorine organic compounds. Meditsina truda i promyshlennaya ekologiya, 2015, no. 12, pp. 29–32 (in Russian).
  37. Zaitseva N.V., Popova A.Yu., Kleyn S.V., Letyushev A.N., Kiryanov D.A., Glukhikh M.V., Chigvintsev V.M. Modifying impact of environmental factors on the course of an epidemic process. Gigiena i sanitariya, 2022, vol. 101, no. 11, pp. 1274–1282. DOI: 10.47470/0016-9900-2022-101-11-1274-1282 (in Russian).
  38. Zaitseva N.V., Shur P.Z., Aminov A.I., Kiryanov D.A., Kamaltdinov M. To estimate the additional risk of diseases of the gastrointestinal tract associated with dysbiosis of the intestinal microflora due to the impact of tetracycline residues in foods. ZNiSO, 2012, no. 7 (232), pp. 46–48 (in Russian).
  39. Zaitseva N.V., Shur P.Z., Atiskova N.G., Kiryanov D.A., Kamaltdinov M.R. Human health hazards associated with tetracycline drugs residues in food. International Journal of Advanced Research, 2014, vol. 2, no. 8, pp. 488–495.
  40. Zaitseva N.V., Shur P.Z., Atiskova N.G., Kiryanov D.A, Kamaltdinov M.R. Safety assessment of the maximum permitted levels of L. monocytogenes in food according to health risk criteria. Health Risk Analysis, 2013, no. 2, pp. 4–13. DOI: 10.21668/health.risk/2013.2.01.eng
  41. Onishchenko G.G., Popova A.Yu., Tutel'yan V.A., Zaitseva N.V., Hotimchenko S.A., Gmoshinsky I.V., Sheveleva S.A., Rakitskij V.N. [et al.]. About the human health safety estimation of ractopamine intake together with the food. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2013, vol. 68, no. 6, pp. 4–8. DOI: 10.15690/vramn.v68i6.666 (in Russian).
  42. Zaitseva N.V., Shur P.Z., Chetverkina K.V., Khasanova A.A. Developing methodical approaches to substantiating average annual maximum permissible concentrations of hazardous substances in ambient air in settlements as per acceptable health risk. Health Risk Analysis, 2020, no. 3, pp. 39–48. DOI: 10.21668/health.risk/2020.3.05.eng
  43. Zaitseva N., Ustinova O.U., Zemlyanova M.A. A strategic approaches to improving prevention of diseases associated with influence of environmental factors. ZNiSO, 2013, no. 11 (248), pp. 14–18 (in Russian).
  44. Zaitseva N.V., Shur P.Z., Goleva O.I. An economic assessment of population health risk in region. Ekonomika regiona, 2012, no. 2 (30), pp. 178–185. DOI: 10.17059/2012-2-16 (in Russian).
  45. Goleva O.I., Shliapnikov D.M. Economic aspects of occupationally conditioned diseases risk (exemplified by potassium salts extraction enterprises). Meditsina truda i promyshlennaya ekologiya, 2016, no. 1, pp. 13–15 (in Russian).
  46. Goleva O.I. Evaluation of tax losses due to mortality and disease rate of population: approaches of evaluation (on the example of Perm region). Perm Finance Journal, 2016, no. 1 (14), pp. 51–59 (in Russian).
  47. Lev M.Yu. Issues of regulating prices for separate food products in the aspect of ensuring the economic security of the Russian Federation. Ekonomika i upravlenie: problemy, resheniya, 2021, vol. 1, no. 7 (115), pp. 19–35. DOI: 10.36871/ek.up.p.r.2021.07.01.003
  48. Kiryanov D.A., Tsinker M.Yu., Goleva O.I. Population health risk management in the economic security system of the country and region. Ekonomicheskaya bezopasnost’, 2021, vol. 4, no. 4, pp. 1195–1222. DOI: 10.18334/ecsec.4.4.113405 (in Russian).
Received: 
31.10.2023
Approved: 
30.11.2023
Accepted for publication: 
20.12.2023

You are here

Home