Some proposals on regulation of highly hazardous chemicals in articles
Kh.Kh. Khamidulina1,2, Е.V. Tarasova1, А.K. Nazarenko1,3, D.N. Rabikova1,2, А.S. Proskurina1,2, I.V. Zamkova1
1The Russian Register of Potentially Hazardous Chemical and Biological Substances – the branch of the Federal Scientifinc Center of Hygiene named after F.F. Erisman of Rospotrebnadzor, 8 Bagrationovskii passage, build. 2, Moscow, 121087, Russian Federation
2Russian Medical Academy for Continuous Occupational Education, 2/1 Barrikadnaya Str., build. 1, Moscow, 125993, Russian Federation
3Mendeleev University of Chemical Technology of Russia, 9 Miusskaya square, build. 6, Moscow, 125047, Russian Federation
When developing safety regulations for chemicals, the international society is constantly searching for safer analogues of highly hazardous chemicals to use as alternatives in various products. Within the Scientific Research Work under the State Program ‘Provision of Chemical and Biological Safety in 2021–2024’, The Russian Register of Potentially Hazardous Chemical and Biological Substances of the Federal Scientific Center of Hygiene named after F.F. Erisman of Rospotrebnadzor has developed a concept on replacement of highly hazardous chemicals in various products (food products, synthetic detergents and household chemicals, pesticides, paints and varnishes, basic chemicals) with their safer analogues. Still, we should highlight that regulation of highly hazardous chemicals in articles has not been developed sufficiently in the RF. Therefore, the purpose of the study was to provide scientific substantiation for criteria and rules for assigning chemicals in articles as prohibited and (or) restricted.
Materials this study is based on are represented by the regulatory legal acts of the Russian Federation, EEC and the EU (in particular, Decrees, Resolutions, Technical Regulations, Directives, Regulations, etc. in the field of safe management of substances of concern), as well as domestic and international databases, scientific articles and monographs containing information on the toxic properties of chemicals.
In order to develop effective measures to minimize the risk of exposure to chemicals in articles and their safe management at all stages of a life cycle, the study provides substantiation of criteria and rules for assigning chemicals in articles as prohibited and (or) restricted and proposes a mechanism for the creation of a National list of chemicals of concern in articles. When created, this List will allow monitoring of their circulation on the territory of the Russian Federation, proper waste disposal, and stimulating research work to find alternatives.
- Tickner J.A., Schifano J.N., Blake A., Rudisill C., Mulvihill M.J. Advancing safer alternatives through functional substitution. Environ. Sci. Technol., 2015, vol. 49, no. 2, pp. 742–749. DOI: 10.1021/es503328m
- Khamidulina Kh.Kh., Proskurina A.S., Tarasova E.V. Development and implementation of a concept for the replacement of highly hazardous substances with safe chemical alternatives. Meditsina truda i promyshlennaya ekologiya, 2022, vol. 62, no. 11, pp. 733–739. DOI: 10.31089/1026-9428-2022-62-11-733-739 (in Russian).
- Khamidulina Kh.Kh., Tarasova E.V., Nazarenko A.K., Rabikova D.N., Proskurina A.S. Proposals for improving the methodic and regulatory framework of the Russian Federation in the field of chemical safety. Toksikologicheskii vestnik, 2023, vol. 31, no. 4, pp. 214–225. DOI: 10.47470/0869-7922-2023-31-4-214-225 (in Russian).
- Dutta S., Sengupta P., Bagchi S., Chhikara B.S., Pavlík A., Sláma P., Roychoudhury S. Reproductive toxicity of combined effects of endocrine disruptors on human reproduction. Front. Cell. Dev. Biol., 2023, vol. 11, pp. 1162015. DOI: 10.3389/fcell.2023.1162015
- Kabir E.R., Rahman M.S., Rahman I. A review on endocrine disruptors and their possible impacts on human health. Environ. Toxicol. Pharmacol., 2015, vol. 40, no. 1, pp. 241–258. DOI: 10.1016/j.etap.2015.06.009
- Assessment and classification of the danger of endocrine disruptors. Toksikologicheskii vestnik, 2023, vol. 31, no. 2, pp. 135–138. DOI: 10.47470/0869-7922-2023-31-2-135-138 (in Russian).
- Filippone A., Rossi C., Rossi M.M., Di Micco A., Maggiore C., Forcina L., Natale M., Costantini L. [et al.]. Endocrine Disruptors in Food, Estrobolome and Breast Cancer. J. Clin. Med., 2023, vol. 12, no. 9, pp. 3158. DOI: 10.3390/jcm12093158
- Zhang J., Qin Q., Li G., Tseng C.-H. Sustainable municipal waste management strategies through life cycle assessment method: A review. J. Environ. Manage., 2021, vol. 287, pp. 112238. DOI: 10.1016/j.jenvman.2021.112238
- Lalit D., Adyasha D., Sitikantha M. Municipal Solid Waste Model Development through Binary Coding. Ecology En-vironment and Conservation, 2022. DOI: 10.53550/EEC.2022.v28i03.069
- Sifakis S., Androutsopoulos V.P., Tsatsakis A.M., Spandidos D.A. Human exposure to endocrine disrupting chem-icals: effects on the male and female reproductive systems. Environ. Toxicol. Pharmacol., 2017, vol. 51, pp. 56–70. DOI: 10.1016/j.etap.2017.02.024
- Zaitseva N.V., May I.V., Kiryanov D.A., Goryaev D.V., Kleyn S.V. Social and hygienic monitoring today: state and prospects in conjunction with the risk-based supervision. Health Risk Analysis, 2016, no. 4, pp. 4–16. DOI: 10.21668/health.risk/2016.4.01.eng
- Jacobs M.M., Malloy T.F., Tickner J.A., Edwards S. Alternatives Assessment Frameworks: Research Needs for the Informed Substitution of Hazardous Chemicals. Environ. Health Perspect., 2016, vol. 124, no. 3, pp. 265–280. DOI: 10.1289/ehp.1409581
- Karthikeyan B.S., Ravichandran J., Mohanraj K., Vivek-Ananth R.P., Samal A. A curated knowledgebase on endocrine disrupting chemicals and their biological systems-level perturbations. Science of the Total Environment, 2019, no. 692, pp. 281–296. DOI: 10.1016/j.scitotenv.2019.07.225
- Antonsson A.B. Substitution of dangerous chemicals – the solution to problems with chemical health hazards in the work environment? Am. Ind. Hyg. Assoc. J., 1995, vol. 56, no. 4, pp. 394–397. DOI: 10.1080/15428119591017024
- Lissner L., Romano D. Substitution for hazardous chemicals on an international level – the approach of the European project “SUBSPORT”. New Solut., 2011, vol. 21, no. 3, pp. 477–497. DOI: 10.2190/NS.21.3.l
- Lofstedt R. The substitution principle in chemical regulation: A constructive critique. Journal of Risk Research, 2014, vol. 17, no. 5. DOI: 10.1080/13669877.2013.841733
- Malloy T., Blake A., Linkov I., Sinsheimer P. Decisions, Science, and Values: Crafting Regulatory Alternatives Analysis. Risk Anal., 2015, vol. 35, no. 12, pp. 2137–2151. DOI: 10.1111/risa.12466
- Oguzcan S., Dvarioniene J., Tugnoli A., Kruopiene J. Environmental impact assessment model for substitution of haz-ardous substances by using life cycle approach. Environ. Pollut., 2019, vol. 254, pt A, pp. 112945. DOI: 10.1016/j.envpol.2019.07.113
- Syeda S.R., Khan E.A., Padungwatanaroj O., Kuprasertwong N., Tula A.K. A perspective on hazardous chemical substitution in consumer products. Current Opinion in Chemical Engineering, 2022, vol. 36, pp. 100748. DOI: 10.1016/j.coche.2021.100748
- Soeteman-Hernández L.G., Hogendoorn E.A., Bakker J., Van Broekhuizen F.A., Palmen N.G.M., Bruinen De Bruin Y., Kooi M., Sijm D.T.H.M., Traas T.P. An approach to identify, prioritise and provide regulatory follow-up actions for new or emerging risks of chemicals for workers, consumers and the environment. International Journal of Risk Assessment and Man-agement, 2018, vol. 21, no. 3, pp. 248–269. DOI: 10.1504/IJRAM.2018.093763