Hygienic assessment of carcinogenic health risks associated with contamination of depositing media with heavy metals

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613.26; 614.3; 614.7

V.M. Boev, L.V. Zelenina, L.H. Kudusova, E.A. Kryazheva, D.O. Zelenin


The Orenburg State Medical University, 6 Sovetskaya Str., Orenburg, 460000, Russian Federation


In nature there are depositing media which are relatively stable macrosystems. Their contamination that occurs due to long-term exposure to contaminants influences population health and this is especially vital for urbanized territories with large city-forming enterprises.

Our research goal was to perform hygienic assessment of carcinogenic risks for population health under exposure to heavy metals contained in depositing media.

We analyzed long-term data on contents of heavy metals in such accumulating media as soils and foods collected in 2005–2018. The data were taken from the reports on social and hygienic monitoring and statistical reports provided by the Orenburg Regional Office of the Federal State Statistics Service. Carcinogenic risks were assessed in accordance with the Guide R We used data provided by the territorial section of the National Cancer Registry to analyze prevalence of oncologic diseases of the digestive organs. We performed correlation analysis to examine correlations between the analyzed factors.

The total carcinogenic risk under multi-route introduction of heavy metals from such depositing media as soils and foods has turned out to be unacceptable and amounts to 1.5E-04. The total population carcinogenic risk caused by exposure to heavy metals can reach 85 additional cases of malignant neoplasms over an averaged exposure period which is equal to 70 years.

Heavy metals were detected in soils, nickel, cadmium, and chromium VI included, that produced statistically authentic effects on occurrence of malignant neoplasms in the digestive organs.

We established an authentic correlation between developing malignant neoplasms in the digestive organs and concentrations of arsenic in foods.
We didn’t detect any heavy metals with carcinogenic properties in such accumulating media as soils and foods in concentrations deviating from hygienic standards. But still, it doesn’t mean there is no negative influence on population health, notably long-term effects and developing malignant neoplasms.

soil contamination, foods, heavy metals, carcinogens, morbidity, carcinogenic risk assessment, malignant neoplasms of the digestive organs
Boev V.M., Zelenina L.V., Kudusova L.H., Kryazheva E.A., Zelenin D.O. Hygienic assessment of carcinogenic health risks associated with contamination of depositing media with heavy metals. Health Risk Analysis, 2022, no. 1, pp. 17–26. DOI: 10.21668/health.risk/2022.1.02.eng
  1. Kargapolov N.V. Geochemical studies in city ecosystems. Sotsial'no-ekologicheskie tekhnologii, 2016, no. 3, pp. 31–37 (in Russian).
  2. Zamotaev I.V., Ivanov I.V., Mikheev P.V., Belobrov V.P. Assessment of the state of soils and vegetation in areas of landfills and municipal solid waste sites (a review). Eurasian soil science, 2018, vol. 51, no. 7, pp. 827–842. DOI: 10.1134/S1064229318070104
  3. Edmondson J.L., Stott I., Davies Z.G., Gaston K.J., Leake J.R. Soil surface temperatures re-veal moderation of the urban heat island effect by trees and shrubs. Sci. Rep., 2016, vol. 6, no. 1, pp. 33708. DOI: 10.1038/srep33708
  4. Benhaddya M., Boukhelkhal A., Halis Y., Hadjel M. Human health risks associated with metals from urban soil and road dust in an oilfield area of Southeastern Algeria. Arch. Environ. Contam. Toxicol., 2016, vol. 70, no. 3, pp. 556–571. DOI: 10.1007/s00244-015-0244-6
  5. Zharikova E.A. Assessment of heavy metals content and environmental risk in urban soils. Izvestiya Tomskogo poli¬tekhnicheskogo universiteta. Inzhiniring georesursov, 2021, vol. 332, no. 1, pp. 164–173. DOI: 10.18799/24131830/2021/1/3009 (in Russian).
  6. Grishchenko S.V., Grishchenko I.S., Kostenko V.S., Zor'kina A.V., Minakov D.G., Ya-kimova K.A. Sovremennye osobennosti kontaminatsii tyazhelymi metallami pishchevykh produktov, proizvedennykh iz mestnogo syr'ya v ekokrizisnom regione [Contemporary peculiarities of contamination with heavy metals of food products produced from local raw materials in the ecocrisis region]. Vestnik gigieny i epidemiologii, 2017, vol. 21, no. 4, pp. 283–287 (in Russian).
  7. Gerson J.R., Driscoll C.T., Demers J.D., Sauer A.K., Blackwell B.D., Montesdeoca M.R., Shanley J.B., Ross D.S. Deposition of mercury in forests across a montane elevation gradient: Ele-vational and seasonal patterns in methylmercury inputs and production. JGR Biogeosciences, 2017, vol. 122, no. 8, pp. 1922–1939. DOI: 10.1002/2016JG003721
  8. Eremin V.N., Reshetnikov M.V., Sheshnev A.S. Impact of waste landfills in the Saratov re-gion on the sanitary condition of the soil. Gigiena i sanitariya, 2017, vol. 96, no. 2, pp. 117–121. DOI: 10.18821/0016-9900-2017-96-2-117-121 (in Russian).
  9. Vekovshinina S.A., Kleyn S.V., Hankhareev S.S., Makarova L.V., Madeeva E.V., Boloshinova A.A. The assessment of environmental quality and risks for the population of the city of Zakamensk – territory of long-term storage of waste of Dzhidinsky tungsten-molybdenum combine. Gigiena i sanitariya, 2017, vol. 96, no. 1, pp. 15–20. DOI: 10.18821/0016-9900-2017-96-1-15-20 (in Russian).
  10. Khan S., Munir S., Sajjad M., Li G. Urban park soil contamination by potentially harmful elements and human health risk in Peshawar city, Khyber Pakhtunkhwa, Pakistan. Journal of Geochemical Exploration, 2016, vol. 165, pp. 102–110. DOI: 10.1016/j.gexplo.2016.03.007
  11. Kumar S., Ghosh S., Mukherjee S., Sarkar S. Chromium and nickel migration study through fine grained soil. J. Hazard. Mater., 2009, vol. 170, no. 2-3, pp. 1192–1196. DOI: 10.1016/j.jhazmat.2009.05.097
  12. Aydinov G.T., Marchenko B.I., Deryabkina L.A., Sinelnikova Yu.A. Chemical factors of soil polution in Taganrog as population health risk factors. Health Risk Analysis, 2017, no. 1, pp. 13–20. DOI: 10.21668/health.risk/2017.1.02.eng
  13. Bashkin V.N., Galiulin R.V., Galiulina R.A., Arabsky A.K. Risk of soil contamination by heavy metals through gas-dust emissions. Problemy analiza riska, 2019, vol. 16, no. 1, pp. 42–49. DOI: 10.32686/1812-5220-2019-16-42-49 (in Russian).
  14. Kaverina N.V. Transformation of urban soils under technogenic impacts. Problemy regional'noi ekologii, 2020, no. 4, pp. 113–117. DOI: 10.24411/1728-323X-2020-14113 (in Russian).
  15. Deryabin A.N., Unguryanu T.N., Buzinov R.V. Population health risk caused by exposure to chemicals in soils. Health Risk Analysis, 2019, no. 3, pp. 18–25. DOI: 10.21668/health.risk/2019.3.02.eng
  16. Radomskaya V.I., Borodina N.A. Assessment of anthropogenic contamination in an urban territory by the example of Blagoveshchensk city. Geoekologiya. Inzhenernaya geologiya, gidrogeologiya, geokriologiya, 2019, no. 6, pp. 79–93. DOI: 10.31857/S0869-78092019679-93 (in Russian).
  17. Al-Saleh I., Abduljabbar M. Heavy metals (lead, cadmium, methylmercury, arsenic) in commonly imported rice grains (Oryza sativa) sold in Saudi Arabia and their potential health risk. Int. J. Hyg. Environ. Health., 2017, vol. 220, no. 7, pp. 1168–1178. DOI: 10.1016/j.ijheh.2017.07.007
  18. Lyzhina A.V., Unguryanu T.N., Rodimanov A.V. Health risk assessment associated with contamination by heavy metals of food products. Zdorov'e naseleniya i sreda obitaniya, 2018, no. 7 (304), pp. 4–7. DOI: 10.35627/2219-5238/2018-304-7-4-7 (in Russian).
  19. Ciannameo V., Ricceri F., Soldati S., Scarnato C., Gerosa A., Giacomozzi G., d'Errico A. Cancer mortality and exposure to nickel and chromium compounds in a cohort of Italian by electroplaters. Am. J. Ind. Med., 2019, vol. 62, no. 2, pp. 99–110. DOI: 10.1002/ajim.22941
  20. Zaitseva N.V., May I.V., Klein S.V., Khankharev S.S., Boloshinova A.A. Scientific and methodological aspects and practical experience for the formation of the evidential base of hazard to health in the population in the zone of influence of waste from the past economic activity. Gigiena i sanitariya, 2017, vol. 96, no. 11, pp. 1038–1044. DOI: 10.18821/0016-9900-2017-96-11-1038-1044 (in Russian).
  21. Cai L.-M., Xu Z.-C., Qi J.-Y., Feng Z.-Z., Xiang T.-S. Assessment of exposure to heavy metals and health risks among residents near Tonglushan mine in Hubei, China. Chemosphere, 2015, vol. 127, pp. 127–135. DOI: 10.1016/j.chemosphere.2015.01.027
  22. Sivukhin A.N., Markov D.S., Borisova E.A. Influence of soil contamination with heavy metals on the population health of the Ivanovo and Kostroma regions. Problemy regional'noi ekologii, 2019, no. 3, pp. 81–87. DOI: 10.24411/1728-323X-2019-13081 (in Russian).
  23. Tikhonova Yu.L., Milushkina O.Yu., Kalinovskaya M.V., Simkalova L.M. The comparative analysis of chemical contamination of food and children’s health indices in the Russian Federation. Zdorov'e naseleniya i sreda obitaniya, 2020, vol. 322, no. 1, pp. 13–18. DOI: 10.35627/2219-5238/2020-322-1-13-18 (in Russian).
  24. Loud J.T., Murphy J. Cancer Screening and Early Detection in the 21st Century. Semin. Oncol. Nurs., 2017, vol. 33, no. 2, pp. 121–128. DOI: 10.1016/j.soncn.2017.02.002
  25. Borschuk E.L., Begun D.N., Klimushkin A.V., Begun T.V., Kulanova A.M. Status and trends of main indicators cancer incidence in the Orenburg region in the 2010s. Sovremennye problemy nauki i obrazovaniya, 2020, no. 6, pp. 127. DOI: 10.17513/spno.30281
  26. Hochberg M.E., Noble R.J. A framework for how environment contributes to cancer risk. Ecol. Lett., 2017, no. 20, pp. 117–134. DOI: 10.1111/ele.12726
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