Risk of circulatory diseases on the example of heart rhythm disorders in patients with sero-logical markers of epstein-barr infection

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UDC: 
614.1: 616.9:616-002.2:616.1
DOI: 
10.21668/health.risk/2021.3.15.eng
Authors: 

T.V. Solomay1,2, T.A. Semenenko3,4, N.N. Filatov 2,4, R.I. Khabazov5, N.V. Dupik5, D.P. Dundua5, N.A. Kolyshkina5, A.V. Konev5

Organization: 

1 The Regional Department No. 1 the FMBA of Russia, 6а, 1 Pekhotny lane., Moscow,123182, Russian Federation
2 I.I. Mechnikov research Institute of vaccines and serums, 5a Maliy Kazenniy lane, Moscow, 105064, Russian Federation
3The National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, 18 Gamaleya Str.,Moscow,123098, Russian Federation
4I.M. Sechenov First Moscow State Medical University, 8/1 Trubetskaya Str., Moscow, 119991, Russian Federation
5 The Federal Scientific and Clinical Center for Sepcilaized medical Aid and Medical technologies, the FMBA of Russia, 28 Orekhoviy blvd., Moscow, 115682, Russian Federation

Abstract: 

To reduce a burden of circulatory diseases (CD) is among primary tasks the state has to solve. There are available data on a contribution made by chronic inflammation on occurrence of heart and vascular diseases. Given that, it seems especially interesting to examine impacts exerted by Epstein-Barr virus infection on CD development.

The paper focuses on analyzing morbidity with infectious mononucleosis and CD in the Russian Federation over 1995–2018. 103 patients with heart rhythm disorders and 92 blood donors were examined to determine whether they had immu-noglobulins to EBV antigens.

The results were statistically processed involving calculation of Pearson’s linear correlation coefficient, error of correlation coefficient, validity coefficient, determination coefficient, and frequencies of EBV markers detection per 100 examined people and their confidence intervals. Differences were considered to be authentic when confidence probability was equal to 95 % and confidence significance was p<0.05. Relative risks of heart rhythm disorders in patients with active EBV-infection were calculated as per results obtained via creating a fourfold table.

EBV was established to make a significant contribution into circulatory pathology occurrence and it was confirmed by an overall ascending trend in morbidity with infectious mononucleosis and CD in the Russian Federation in 1995-2018 and an authentic strong direct correlation between these two processes (r=0.94; m=0.02; t=47; p<0.01) with determination being equal to 0.88. Risk of developing heart rhythm disorders was determined by active EBV-infection in case history combined with detected M-immunoglobulins to capsid EBV antigen and G-immunoglobulins to early EBV antigen, as well as an increase in concentration of G-immunoglobulins to capsid antigen in blood serum (RR=5.8 and 2.3 accordingly).

These detected peculiarities require further more profound study and development of activities aimed at risk minimization.

Keywords: 
Epstein-Barr virus, circulatory diseases, infectious mononucleosis, morbidity, heart rhythm disorders, blood donors, relative risk, positivity rate
Solomay T.V., Semenenko T.A., Filatov N.N., Khabazov R.I., Dupik N.V., Dundua D.P., Kolyshkina N.A., Konev A.V. Risk of circulatory diseases on the example of heart rhythm disorders in patients with serological markers of Epstein – Barr infection. Health Risk Analysis, 2021, no. 3, pp. 146–155. DOI: 10.21668/health.risk/2021.3.15.eng
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Received: 
31.05.2021
Accepted: 
14.09.2021
Published: 
30.09.2021

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