Markers showing allergic reactions in children caused by aerogenic exposure to manganese and nickel compounds

View or download the full article: 

S.L. Valina1, I.E. Shtina1, O.A. Maklakova1,2, D.A. Eisfel'd1, O.Yu. Ustinova1,2


1Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation
2Perm State University, 15 Bukireva Str., Perm, 614990, Russian Federation


High prevalence of allergic diseases among children and their close relation with quality of the environment require new approaches to organizing diagnostic and prevention activities.
Our research objects were 247 children attending pre-school children facilities (PSCF).
It was detected that children who permanently lived and/or attended a pre-school facility for not less than three years under long-term chemical aerogenic exposure to manganese and nickel compounds in low doses (0.17–0.23 MPC average daily) had contents of these metals in their blood that were 1.9–2.0 times higher than the same parameter in children from the reference group and 1.7–2.1 times higher than background level in the region. Pre-school children with their biological media being contaminated with nickel and manganese compounds suffered from atopic dermatitis, allergic rhinitis, and bronchial asthma 1.3–4.5 times more frequently (0.23R20.73; 59.2F388.1; р≤0.001).
Allergic diseases associated with aerogenic exposure to chemicals with sensitizing power have certain pathogenetic peculiarities such as active overall inflammatory reaction; sensitization in 54–86% children (the parameter is 1.5–4.3 times higher than in the reference group); cellular metabolism disorder; depletion of antioxidant protection resources in 72% children; deficient activity of phagocytic and humoral section in immunity (1.2 times lower than in the reference group); cytokine regulation disorders (2.4–2.5 time difference); reduced expression of a receptor that induces activation apoptosis; stronger sympathetic influence on heart rate modulation in 26.0% children. Basing on statistical analysis and model making, we determined markers that showed occurring allergic reactions caused by aerogenic exposure to manganese and nickel compounds. These markers are targets for prevention activities; they include growth in allergic pathologies prevalence; these pathologies occurring together with chronic inflammatory-proliferative diseases and disorders in the vegetative nervous system; increased contents of leukocytes, eosinophils, and immunoglobulin E specific to nickel in blood; a decrease in phagocyte number and contents of IgM, IgА in blood serum (0.07≤R2≤0.74; 19.3≤F≤713.2; р≤0.0001).

allergic diseases, pre-school children, ambient air, chemicals with sensitizing power, manganese, nickel, markers
Valina S.L., Shtina I.E., Maklakova O.A., Eisfel'd D.A., Ustinova O.Yu. Markers showing allergic reactions in children caused by aerogenic exposure to manganese and nickel compounds. Health Risk Analysis, 2020, no. 4, pp. 84–91. DOI: 10.21668/health.risk/2020.4.09.eng
  1. Balabolkin I.I., Terletskaya R.N. Allergic case rate of children and adolescents in the modern ecological conditions. Pediatr, 2014, vol. 5, no. 2, pp. 40–46 (in Russian).
  2. Burlutskaya A.V., Firsova V.N., Sutovskaya D.V., Tralenko E.S., Dremlyugova A.F. Anti-inflammatory antileukotrienes efficiency (almont as an example) to control bronchial asthma and allergic rhinitis in children. Mezhdunarodnyi nauchno-issledovatel'skii zhurnal, 2017, no. 1–1 (55), pp. 90–97 (in Russian).
  3. Gurtovaya M.N., Prokop'ev N.Ya., Kolunin E.T., Gubin D.G., Durov A.M. Allergic rhinitis and bronchial asthma: the incidence, causes, and treatment (review of foreign literature). Mezhdunarodnyi zhurnal prikladnykh i fundamental'nykh issledovanii, 2016, no. 10 (1), pp. 29–37 (in Russian).
  4. Shvetsova E.S., Korotkova T.S. The prevalence of allergic diseases among all age groups of the population of Lipetsk region. Sovremennye problemy nauki i obrazovaniya, 2017, no. 4, pp. 92–93 (in Russian).
  5. Ballardini N., Kull I., Lind T., Hallner E., Almqvist C., Ostblom E., Melén E., Pershagen G. [et al.]. Development and comorbidity of eczema, asthma and rhinitis to age 12: data from the BAMSE birth cohort. Allergy, 2012, vol. 67, no. 4, pp. 537–544. DOI: 10.1111/j.1398-9995.2012.02786.x
  6. Oh I., Lee J., Ahn K., Kim J., Kim Y.-M., Sim C.S., Kim Y. Association between particulate matter concentration and symptoms of atopic dermatitis in children living in an industrial urban area of South Korea. Environ Res, 2018, no. 160, pp. 462–468. DOI: 10.1016/j.envres.2017.10.030
  7. Shima M. Health Effects of Air Pollution: A Historical Review and Present Status. Nihon Eiseigaku Zasshi, 2017, vol. 72, no. 3, pp. 159–165. DOI: 10.1265/jjh.72.159
  8. Nesterova A.V., Potaturkina-Nesterova N.I., Nesterov A.S. The current state of the problem of allergic rhinitis in children. Sovremennye problem nauki i obrazovaniya, 2015, no. 5, pp. 226–227 (in Russian).
  9. Sineva E.L., Pankova V.B., Sarancha E.O. The prevalence and structure of ENT diseases in the children residing in the industrial regions. Vestnik otorinolaringologii, 2015, vol. 80, no. 2, pp. 48–52 (in Russian).
  10. Ernazarova Kh.Kh., Adylova Z.U. The prevalence of allergic diseases in the world. International scientific review, 2017, no. 2 (33), pp. 48–52 (in Russian).
  11. Paciencia I., Rufo J.C., Silva D., Martins C., Mendes F., Rama T., Rodolfo A., Madureira J. [et al.]. School environment associates with lung function and autonomic nervous system activity in children: a cross-sectional study. Scientific Reports, 2019, no. 9, pp. 15156. DOI: 10.1038/s41598-019-51659-y
  12. Kleyn S.V., Vekovshinina S.A., Balashov S.Yu., Kamaltdinov M.R., Atiskova N.G., Nedoshitova A.V., Khankhareev S.S., Madeeva E.V. Analysis of cause-effect relations of the levels of biological markers of exposure to heavy metals with their personalized loading dose in the areas of wastes' influence induced by the operation of the metallurgical plant in the past. Gigiena i sanitariya, 2017, vol. 96, no. 1, pp. 29–35 (in Russian).
  13. Dolgikh O.V., Krivtsov A.V., Bubnova O.A., Otavina E.A., Bezruchenko N.V., Kolegova A.A., Mazunina A.A., Gusel'nikov M.A. Features of fixing the genetic polymorphism in dyads «mother-child» in the conditions of aerogenous exposure to metals. Gigiena i sanitariya, 2017, vol. 96, no. 1, pp. 26–29 (in Russian).
  14. Arruti A., Fernández-Olmo I., Irabien A. Impact of the global economic crisis on metal levels in particulate matter (PM) at an urban area in the Cantabria Region (Northern Spain).Environ Pollut, 2011, no. 159 (5), pp. 1129–1135. DOI: 10.1016/j.envpol.2011.02.008
  15. Zanoletti A., Bilo F., Borgese L., Depero L.E., Fahimi A., Ponti J., Valsesia A., La Spina R., Montini T., Bontempi E. SUNSPACE, A Porous Material to Reduce Air Particulate Matter (PM). Front Chem, 2018, no. 6, pp. 534. DOI: 10.3389/fchem.2018.00534
  16. Zaitseva N.V., Ustinova O.Yu., Sboev A.S. Medical and preventive technologies for risk management of health problems associated with exposure to environmental factors. Gigiena i sanitariya, 2016, vol. 95, no. 1, pp. 17–22 (in Russian).
  17. Maklakova O.A., Ustinova O.Yu., Alekseeva A.V. Age structure and dynamics of the morbidity rate of respiratory and autonomous nervous system diseases in children living in conditions of the aerogenous impact of chemical factors of technogenic origin (cohort study). Gigiena i sanitariya, 2017, vol. 96, no. 1, pp. 75–78 (in Russian).
  18. Simonova I.N., Antonyuk M.V. Role of industrial air pollution in growth of bronchopulmonary pathology. Zdorov'e. Meditsinskaya ekologiya. Nauka, 2015, no. 1 (59), pp. 14–20 (in Russian).
  19. Khismatullina Z.N. Zabolevaniya, svyazannye s vozdeistviem khimicheskikh faktorov okruzhayushchei sredy [Diseases caused by exposure to chemical environmental factors]. Vestnik Kazanskogo tekhnologicheskogo universiteta, 2013, vol. 16, no. 20, pp. 170–178 (in Russian).
  20. Silvestre M.C., Dos Reis V.M.S. Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases. An Bras Dermatol, 2018, vol. 93, no. 6, pp. 829–835. DOI: 10.1590/abd1806-4841.20187126

You are here