Stroke and air pollution. a worldwide public health problem

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UDC: 
614.72:616.8
DOI: 
10.21668/health.risk/2020.3.02.eng
Authors: 

M. Giroud1, J. Reis2

Organization: 

1University Hospital of Dijon, 2 Boulevard du Maréchal de Lattre de Tassigny, 21000, Dijon, France
2University of Strasbourg, 3 rue du loir, Oberhausbergen, Strasbourg, 67205, France

Abstract: 

After myocardial infarction, stroke is now associated with air pollution.
From local data and literature, we report the strength of the association between air pollution and stroke. We try to understand the biological mechanisms between exposure to air pollutants and stroke risk.
The association between air pollution and stroke is strong, confirmed and real. Air pollution and small particulate matter are the most toxic. Patients with classical neuro-vascular risk factors or a history of stroke or transient ischemic attack are at risk of stroke induced by air pollution.
Air pollution is a serious modifiable risk factor for stroke and a silent killer inducing stroke. This new neuro-vascular risk factor is useful for public health policies.

Keywords: 
ischaemic stroke, hemorrhagic stroke, stroke, air pollution, air pollutants
Giroud M., Reis J. Stroke and air pollution. a worldwide public health problem. Health Risk Analysis, 2020, no. 3, pp. 19–22. DOI: 10.21668/health.risk/2020.3.02.eng
References: 
  1. Graber M., Mohr S., Baptiste L., Duloquin G., Blanc-Labarre C., Mariet A.S., Giroud M., Béjot Y. Air pollution and stroke. A new modifiable risk factor is in the air. Revue Neurologique, 2019, vol. 175, no. 10, pp. 619–624. DOI: 10.1016/j.neurol.2019.03.003
  2. Lee K.K., Miller M.R., Shah A.D. Air pollution and stroke. Journal of Stroke, 2018, vol. 20, no. 1, pp. 2–11. DOI: 10.5853/jos.2017.02894
  3. Maheswaran R. Air pollution and stroke. An overview of the evidence base. Spatiotemporal Epidemiol, 2016, no. 18, pp. 74–81. DOI: 10.1016/j.sste.2016.04.004
  4. Cassee F.R., Heroux M.E., Gerlofs-Nijland M.E., Kelly F.J. Particulate matter beyond mass: recent health evidence on the role of fractions, chemical constituent and sources of emission. Inhal Toxicol, 2013, no. 25, pp. 802–812. DOI: 10.3109/08958378.2013.850127
  5. Ljungman P.L., Mittleman M.A. Ambient air pollution and stroke. Stroke, 2014, no. 45, pp. 3734–3441. DOI: 10.1161/STROKEAHA.114.003130
  6. Scheers H., Jacobs L., Casas I., Nemery B., Nawrot T.S. Long-term exposure to particulate matter air pollution is a risk factor for stroke: meta-analytical evidence. Stroke, 2015, vol. 46, pp. 3058–2066. DOI: 10.1161/STROKEAHA.115.009913
  7. Kulick E.R., Wellenius G.A., Boehme A.K., Sacco R.L., Elkind M.S. Residential proximity to major roadways and risk of incident ischemic stroke in NOMAS (The Northern Manhattan Study). Stroke, 2018, vol. 49, pp. 835–841. DOI: 10.1161/STROKEAHA.117.019580
  8. Maheswaran R., Pearson T., Smeeton N.C., Beevers S.D., Campbell M.J., Wolfe C.D. Impact of outdoor air pollution on survival after stroke: population-based cohort study. Stroke, 2010, vol. 41, pp. 869–877. DOI: 10.1161/STROKEAHA.109.567743
  9. Zhang R., Liu G., Jiang Y., Li G., Pan Y., Wang Y., Wei Z., Wang J., Wang Y. Acute effects of particulate air pollution on ischemic stroke and hemorrhagic stroke mortality. Frontiers in Neurology, 2018, no. 9, pp. 827. DOI: 10.3389/fneur.2018.00827
  10. Yang W.S., Wang X., Deng Q., Fan W.-Y., Wang W.-Y. An evidence-based appraisal of global association between air pollution and risk of stroke. Int. J. Cardiol, 2014, vol. 175, no. 2, pp. 307–313. DOI: 10.1016/j.ijcard.2014.05.044
  11. Shah A.S., Lee K.K., McAllister D.A., Hunter A., Nair H., Whiteley W., Langrish J.P., Newby D.E. [et al.]. Short term exposure to air pollution and stroke: systematic review and meta-analysis. BMJ, 2015, vol. 350, pp. h1295. DOI: 10.1136/bmj.h1295
  12. Wang Y., Eliot N., Wellenius G.A. Short-term changes in ambient particulate matter and risk of stroke: a systematic review and meta-analyses. J. Am. Heart. Assoc, 2014, no. 3, pp. e00093. DOI: 10.1161/JAHA.114.000983
  13. Henrotin J.B., Besancenot J.P., Bejot Y., Giroud M. Short-term effects of ozone air pollution on ischemic stroke occurrence: a case-crossover analysis from a 10-year population-based study in Dijon, France. Occup. Environ. Med., 2007, no. 64, pp. 439–445. DOI: 10.1136/oem.2006.029306
  14. Maheswaran K., Pearson T., Beevers S.D., Campbell M.J., Wolfe C.D. Air pollution and subtypes, severity and vulnerability to ischemic stroke. A population-based case-crossover study. PLoS One, 2016, no. 11, pp. e0158556. DOI: 10.1371/journal.pone.0158556
  15. Feigin V.L., Roth G.A., Nathavi M., Parmar P., Krishanamurthi R., Chugh S., Mensah G.A., N. Bo [et al.]. Global Burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet Neurol., 2016, vol. 15, pp. 913–924. DOI: 10.1016/S1474-4422(16)30073-4
  16. Oberdörster G., Sharp Z., Atudorei V., Elder A., Gelein R., Lunts A., Kreyling W., Cox C. [et al.]. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health A., 2002, no. 65, pp. 1531–1543. DOI: 10.1080/00984100290071658
  17. Aung H.H., Lame M.W., Gohil K., He G., Denison M.S., Rutledge J.C., Wilson D.V. Comparative gene responses to collected ambient particles in vitro: endothelial responses. Physiol. Genomics, 2011, vol. 43, no. 15, pp. 917–929. DOI: 10.1152/physiolgenomics.00051.2011
  18. Chao M.W., Kozlosky J., Po I.P., Strickland P.O., Svoboda K.K., Cooper K., Laumbach R.J., Gordon M.K. Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin. Toxicology, 2011, vol. 279, pp. 73–84. DOI: 10.1016/j.tox.2010.09.011
  19. Chung J.W., Bang O.Y., Ahn K., Park S.S., Park T.H., Kim J.G., Ko Y., Lee S. [et al.]. Air pollution is associated with ischemic stroke via cardiogenic embolism. Stroke, 2017, vol. 48, no. 1, pp. 17–23. DOI: 10.1161/STROKEAHA.116.015428
  20. Fraineau S., Palii C.G., Allan D.S., Brand M. Epigenetic regulation of endothelial-cell-mediated vascular repair. FEBS Journal, 2015, vol. 282, no. 9, pp. 1605–1629. DOI: 10.1111/febs.13183
Received: 
16.04.2020
Accepted: 
18.08.2020
Published: 
30.09.2020

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