Influence exerted by inhalation burden with formaldehyde on cytokines level in teenagers living in industrial centers

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UDC: 
614.71:612.017.1-053.6
DOI: 
10.21668/health.risk/2020.2.12.eng
Authors: 

L.B. Masnavieva, I.V. Kudaeva

Organization: 

East-Siberian Institute of Medical and Ecological Research, 12 a the 3rd micro-district, Angarsk, 665827, Russian Federation

Abstract: 

The atmospheric air is polluted with formaldehyde and it exerts negative influence on population health; first of all, the immune system suffers as it is the most sensitive to impacts exerted by environmental factors. Our research goal was to examine levels of specific auto-antibodies and cytokines in teenagers depending on an individual inhalation burden with formaldehyde. We calculated a personified hazard index of inhalation exposure to formaldehyde for each school student. A formula for its calculation included data on air pollution with formaldehyde inside school rooms and teenagers' homes, the atmospheric air pollution, anthropometric and spirometry data, as well as data on school students' daily regime. We examined cytokines and specific auto-antibodies in blood serum of teenagers as these two parameters reflected the immune system state. We revealed correlations between a hazard quotient for exposure to formaldehyde and contents of auto-antibodies to β2-glycoprotein I and to Fc-fragment of IgG, levels of interleukin-2, alpha- and gamma-interferon. We also detected that a share of people with elevated immune reactivity of auto-antibodies to β2-glycoprotein I and to Fc-fragment of IgG increased as the hazard quotient for exposure to formaldehyde grew. Correlations between the examined parameters of the immune system grew in their strength and number and it proved that pro- and anti-inflammatory processes became more conjugated under inhalation exposure to formaldehyde that was higher than the reference level. Teenagers with their hazard quotient for exposure to formaldehyde was higher than 1 tended to have lower concentrations of interleukin-2, alpha- and gamma-interferons, and there was strain in their system of pro- and anti-inflammatory processes as inhalation burden with formaldehyde became greater.

Keywords: 
air pollution, inhalation load, formaldehyde, adolescents, the immune system, interleukins, interferons, autoantibodies
Masnavieva L.B., Kudaeva I.V. Influence exerted by inhalation burden with formaldehyde on cytokines level in teenagers living in industrial centers. Health Risk Analysis, 2020, no. 2, pp. 110–116. DOI: 10.21668/health.risk/2020.2.12.eng
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Received: 
22.11.2018
Accepted: 
03.06.2020
Published: 
30.06.2020

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