Assessing dietary risks caused by food additives: A case study of total diet in Vietnam

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Nguyen Hung Long1, Le Thi Hong Hao2, Vu Thi Trang2, Tran Cao Son2, Lam Quoc Hung2


1Vietnam Food Administration, 138A Giảng Võ Ba Đình, Hanoi, Vietnam
2National Institute for Food Control, 65 Phạm Thận Duật, Hanoi, Vietnam


A risk assessment study of 6 types of food additives (including benzoates, sorbates, cyclamate, saccharin, tartrazine, and sunset yellow) in Vietnamese diets was conducted based on the food consumption research and food additives concentration followed by the guideline of World Health Organization. Surveys on food consumption and food sampling were conducted in 6 provinces including Ha Noi, Ho Chi Minh, Thua Thien Hue, Nam Dinh, Tay Ninh and Quang Tri. The survey results have determined the amount of food consumed for each different food product groups on different age groups. Test results of 6 food additives including benzoates, sorbates, saccharins, cyclamates, tartrazine and sunset yellow FCF using HPLC method show that benzoates and sorbates are the two most discovered groups of substances in the tested samples. The highest concentrations of these compounds were on jelly, soft drinks, ground meat, chilli sauce … Types of food additives used as sweeteners are common in dried fruits, jam; the cyclamate content was very high in these two product groups. The colouring agents content were at a much lower level, mainly found in chili sauce. Risk assessment results show that total intake of sorbate and benzoate in the group of children under 5 years old were the highest value, which was 38 % of ADI. For all other age groups, the risk ranged from 10.6 to 34.0 % ADI for benzoates and from 0.56 to 1.8 % ADI for sorbates. For the remaining 4 food additives, total consumption was much lower than their ADIs. With the assumption that people used all types of food, 0.8 % of the population had the intake of benzoate exceed its ADI.

Nguyen Hung Long, Le Thi Hong Hao, Vu Thi Trang, Tran Cao Son, Lam Quoc Hung. Assessing dietary risks caused by food additives: a case study of total diet in Vietnam. Health Risk Analysis, 2019, no. 2, pp. 74–82. DOI: 10.21668/health.risk/2019.2.08.eng
  1. Codex Alimentarius. General standard for food additives. Codex Stan 192–1995, 2018, 475 p.
  2. Le T.H.H., Nguyen T.Q.H., Tran C.S., Vu T.T., Nguyen T.L., Cao V.H. [et al.]. Screening determination of food additives using capillary electrophoresis coupled with contactless conductivity detection: A case study in Vietnam. Food Control, 2017, vol. 77, pp. 281–289.
  3. Hoang Y.T.H., Vu A.T.L. Sodium Benzoate and Potassium Sorbate in Processed Meat Products Collected in Ho Chi Minh City. International Journal on Advanced Science Engineering Information Technology, 2016, vol. 6, no. 4, pp. 477–482.
  4. Principles and methods for the risk assessment of chemicals in food. Stuttgart, World Health Organization Publ., 2009, 95 p.
  5. Galli C.L., Marinovich M., Lotti M. Is the acceptable daily intake as presently used as an axiom or a dogma. Toxicology Letters, 2008, vol. 180, pp. 93–99.
  6. Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 202), potassium benzoate (E211) and calcium sorbate (E 213) as food additives. EFSA Journal, 2016, vol. 14, no. 3, pp. 4433. DOI: 10.2903/j.efsa.2016.4433
  7. Scientific Opinion on the re-evaluation of sorbic acid (E 200), potassium sorbate (E 202) and calcium sorbate (E 203) as food additives. EFSA Journal, 2015, vol. 13, no. 6, pp. 4144. DOI: 10.2903/j.efsa.2015.4144
  8. Scientific Opinion on the re-evaluation of sunset yellow FCF (E 110) as a food additive. EFSA Journal, 2009, vol. 7, no. 11, pp. 1330. DOI: 10.2903/j.efsa.2009.1330
  9. Scientific Opinion on the re-evaluation of tartrazine (E 102). EFSA Journal, 2009, vol. 7, no. 11, pp. 1331. DOI: 10.2903/j.efsa.2009.1331
  10. Opinion on saccharin and its sodium, potassium and calcium salts. European commission, CS/ADD/EDUL/148-F. Brussels, 1997, 8 p. Available at: (03.06.2019).
  11. Food Additives Data Book. Second edition. In: J. Smith, L. Hong-Shum eds. West Sussex, Wiley-Blackwell Publ., 2011, 1128 p.
  12. Cressey P., Jones S. Levels of preservatives (sulfite, sorbate and benzoate) in New Zealand foods and estimated dietary exposure. Food Additives & Contaminants. Part A, 2009, vol. 26, no. 5, pp. 604–613.
  13. Bemrah N., Leblanc J.C., Volatier J.L. Assessment of dietary exposure in the French population to 13 selected food colours, preservatives, antioxidants, stabilizers, emulsifiers and sweeteners. Food Additives & Contaminants. Part B, 2008, vol. 1, no. 1, pp. 2–14.
  14. Chung M.S., Suh H.J., Yoo W., Choi S.H., Cho Y.J., Kim C.J. Daily intake assessment of saccharin, stevioside,
    D-sorbitol and aspartame from various processed foods in Korea. Food Additives & Contaminants, 2005, vol. 22, no. 11, pp. 1087–1097.
  15. Ha M.S., Ha S.D., Choi S.H., Bae D.H. Assessment of Korean consumer exposure to sodium saccharin, aspartame and stevioside. Food Additives & Contaminants. Part A, 2013, vol. 30, no. 7, pp. 1238–1247.
  16. Ha M.S., Ha S.D., Choi S.H., Bae D.H. Exposure assessment of synthetic colours approved in Korea. Food Additives & Contaminants. Part A, 2013, vol. 30, no. 4, pp. 643–653.
  17. Rao P., Bhat R.V., Sudershan R.V., Krishna T.P., Naidu N. Exposure assessment to synthetic food colours of a selected population in Hyderabad, India. Food Additives & Contaminants, 2004, vol. 21, no. 5, pp. 415–421.
  18. Dixit S., Purshottam S.K., Khanna S.K., Das M. Usage pattern of synthetic food colours in different states of India and exposure assessment through commodities preferentially consumed by children. Food Additives & Contaminants. Part A, 2011, vol. 28, no. 8, pp. 996–1005.
  19. Nguyen V.A., Bang S., Pham H.V., Kim K.W. Contamination of groundwater and risk assessment for arsenic exposure in Ha Nam province, Vietnam. Environment International, 2009, vol. 35, no. 3, pp. 466–472.
  20. Bui T.M.H., Le D.T., Tran T.D., Madsena H., Brimer L. Dalsgaard A. Aflatoxins and fumonisins in rice and maize staple cereals in Northern Vietnam and dietary exposure in different ethnic groups. Food Control, 2016, vol. 70, pp. 191–200.
  21. Bui T.M.H, Le D.T., Do H.T., Brimer L., Dalsgaard A. Dietary exposure to aflatoxin B1, ochratoxin A and fuminisins of adults in Lao Cai province, Viet Nam: A total dietary study approach. Food and Chemical Toxicology, 2016, vol. 98 (Part B), pp. 127–133.

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