Hygienic assessment of population health risks caused by combined oral introduction of heavy metals

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V.M. Boev, E.A. Kryazheva, D.N. Begun, E.L. Borshchuk, D.A. Kryazhev


The Orenburg State Medical University, 6 Sovetskaya Str., Orenburg, 460000, Russian Federation


There is a pressing issue related to combined oral introduction of heavy metals into a human body with drinking water and food products. It is caused by food products contamination, very high probability that metals migrate into water and plants from soils, ambient air, etc. The research goal was to hygienically assess combined oral introduction of heavy metals with drinking water and food products with subsequent population health risks assessment. The authors analyzed long-term data on structure and volumes of food products consumption and assessed population exposure under combined oral introduction of heavy metals (mercury, cadmium, arsenic, and lead) contained in drinking water and food products. Data were obtained from a regional information social-hygienic monitoring database and a regional office of the Federal Statistics Service. Both regional products and products delivered from other regions (or countries) were analyzed. It was detected that population in the region consumed food products per 1 person a year in a quantity which was by 93 kg higher than on average in the country. Calculated concentrations of the examined substances in food products and drinking water corresponded to hygienic standards. Dairy products had the first rank place as regards a contribution made into the overall exposure to lead, cadmium, and arsenic. The second and the third place belonged to vegetables and melons and grocery respectively. The first rank place as per a contribution made into the overall exposure to mercury belonged to vegetables and melons; the second place, to grocery; the third place, to dairy products. Non-carcinogenic risk assessment revealed that hazard quotients related to heavy metals contents in food products and drinking water were within acceptable risks limits. Total carcinogenic risk (TCR) was unacceptable (1.5Е-03.). A number of additional oncologic diseases in the region could reach 557 cases (during 70 years) under the worst scenario.

food products, drinking water, heavy metals, health risk assessment, non-carcinogenic risk, oncologic diseases, combined effect, oral introduction
Boev V.M., Kryazheva E.A., Begun D.N., Borshchuk E.L., Kryazhev D.A. Hygienic assessment of population health risks caused by combined oral introduction of heavy metals. Health Risk Analysis, 2019, no. 2, pp. 35–43. DOI: 10.21668/health.risk/2019.2.04.eng
  1. Shur P.Z., Zaitseva N.V., Khotimchenko S.A., Fedorenko E.V., Sychik S.I., Fokin V.A., Suvorov D.V., Zelenkin S.E. On the issue of establishing acceptable daily intake of chemical substancesin food products according to health risk criteria. Gigiena i sanitariya, 2019, vol. 98, no. 2, pp. 189–195. DOI: 10.18821/0016-9900-2019-98-2-189-195 (in Russian).
  2. Popova A.Yu. Strategic priorities of the Russian Federation in the field of ecology from the position of preservation of health of the nation. Zdorov'e naseleniya i sreda obitaniya, 2014, vol. 251, no. 2, pp. 4–7 (in Russian).
  3. May I.V., Nikiforova N.V. Methodological approaches to optimization of the laboratory control over product safety within risk-based surveillance framework // Gigiena i sanitariya, 2019, vol. 98, no. 2, pp. 205–213. DOI: 10.18821/0016-9900-2019-98-2-205-213 (in Russian).
  4. Rakitskii V.N., Avaliani S.L., Shashiia T.A., Dodina N.S. Actual problems of population health risks management in Russia. Gigiena i sanitariya, 2018, vol. 97, no. 6, pp. 572–575 (in Russian).
  5. Rakhmanin Yu.A., Mikhailova R.I. Food risks analysis and water safety. Health Risk Analysis, 2018, no. 4, pp. 31–42. DOI: 10.21668/health.risk/2018.4.04.eng
  6. Fomina S.F., Stepanova N.V. Izuchenie pitaniya detei g. Kazani i risk zabolevaemosti, svyazannyi s khimicheskoi kontaminatsiei pishchevykh produktov [The study of the nutrition of children in Kazan and the risk of morbidity associated with chemical contamination of food]. Voprosy pitaniya, 2018, vol. 87, no.S5, pp. 197–198 (in Russian).
  7. Fridman K.B., Novikova Yu.A., Belkin A.S. On the issue of the use of health risk assessment techniques for hygienic characteristics of water supply systems. Gigiena i sanitariya, 2017, vol. 96, no. 7, pp. 686–689 (in Russian).
  8. Ivashkevich L.S., Kovshova T.V., Vashkova O.N., Velentei Yu.N. Working out procedures for analyzing toxic elements content in oil products and oil raw materials using atomic emission spectrometry with inductive-bound plasma to assess products safety. Health Risk Analysis, 2017, no. 2, pp. 128–135. DOI: 10.21668/health.risk/2017.2.14.eng
  9. Zaitseva N.V., Trusov P.V., Kir'yanov D.A. Mathematic concept model of accumulation of functional disorders associated with environmental factors. Meditsina truda i promyshlennaya ekologiya, 2012, no. 12, pp. 40–45.
  10. Milošković A., Milošević Đ., Radojković N., Radenković M., Đuretanović S., Veličković T., Simić V. Potentially toxic elements in freshwater (Alburnus spp.) and marine (Sardina pilchardus) sardines from the Western Balkan Peninsula: An assessment of human health risk and management. Science of the Total Environment, 2018, vol. 644, no. 10, pp. 899–906. DOI: 10.1016/j.scitotenv.2018.07.041
  11. Vejarano R., Siche R. Evaluation of biological contaminants in foods by hyperspectral imaging: A review. International Journal of Food Properties, 2017, vol. 20, pp. 1264–1297. DOI: 10.1080/10942912.2017.1338729
  12. Kiku P.F., Kislitsyna L.V., Bogdanova V.D., Sabirova K.M. Hygienic evaluation of the quality of drinking water and risks for the health of the population of the primorye territory. Gigiena i sanitariya, 2019, vol. 98, no. 1, pp. 94–101 (in Russian).
  13. Boev V.M., Lestsova N.A., Amerzyanova N.M., Makarova T.M., Sizova G.V., Setko A.G., Utenin V.V. Hygienic as-sessment of the levels of trace elements in drinking water and foodstuffs in the sociohygienic monitoring system. Gigiena i sanitariya, 2002, no. 5, pp. 71–73 (in Russian).
  14. Zholdakova Z.I., Kharchevnikova N.V., Mamonov R.A., Sinitsyna O.O. Methods for estimating the combined effect of substances. Gigiena i sanitariya, 2012, no. 2, pp. 86–90 (in Russian).
  15. Liu Y., Liu G., Yuan Z., Liu H., Lam P.K.S. Presence of arsenic, mercury and vanadium in aquatic organisms of Laizhou Bay and their potential health risk. Marine Pollution Bulletin, 2017, vol. 125, no. 1–2, pp. 176–185.
  16. Kislitsyna L.V., Ivanova I.L., Kiku P.F. Estimation of risk of the likely impact of heavy metals in food on health of population of the Primorsky region. Zdorov'e. Meditsinskaya ekologiya. Nauka, 2015, no. 4 (62), pp. 78–83 (in Russian).
  17. FrolovaO.A., Tafeeva E.A., Frolov D.N., Bocharov E.P. Alimentary-dependent diseases of the population and the hy-gienic characteristic of the factors of the risk of their development in the territory of the republic of Tatarstan. Gigiena i sanitariya, 2018, vol. 97, no. 5, pp. 470–473 (in Russian).
  18. Lyzhina A.V., Unguryanu T.N., Rodimanov A.V. Health risk assessment associated with contamination by heavy metals of food products. Zdorov'e naseleniya i sreda obitaniya, 2018, no. 7 (304), pp. 4–7 (in Russian).
  19. Boev V.M., Zelenina L.V., Kryazhev D.A., Tulina L.M., Neplokhov A.A. Analysis on exposure carcinogenic risk of environmental factors on health largest industrial cities and malignant tumors. Zdorov'e naseleniya i sreda obitaniya, 2016, no. 6, pp. 3–6 (in Russian).

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