On quantitative assessment of microbe risk caused by exposure to enteric viruses in drinking water

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E.V.Baydakova1,2, T.N. Unguryanu1,2, R.I. Mikhailova3


1Arkhangelsk Region Department of the Federal Service on Customers' Rights Protection and Human Well-Being Surveillance, 24 Gaidar St., Arkhangelsk, 163000, Russian Federation
2Northern State Medical University, 51 Troitsky Av., Arkhangelsk, 163000, Russian Federation
3Centre for Strategic Planning and Management of Biomedical Health Risks, Russian Ministry of Health, Bldg. 1, 10 Pogodinskaya Sr., Moscow, 119121, Russian Federation


The authors assessed microbiological risks of acute intestinal infections (AII) with viral etiology caused by drinking water taken from centralized water supply systems among overall urban population in Arkhangelsk region over 2006-2017. The re-search was performed with Quantitative Microbial Risk Assessment (QMRA) procedure. It was revealed that acute intestinal viral infections prevailed among intestinal infections; the most widely spread ones were rotavirus infection (86.9%), norovirus infection (7.7%), and enterovirus infection (3.7%). The authors also performed comparative analysis of spatial distribution and long-term dynamics of incidence with AII which were possibly caused by infectious agents entering a body with water. The analysis revealed that rotavirus and norovirus infections frequently occurred in Arkhangelsk, Novodvinsk, Koryazhma, and Kotlas. Incidence with rotavirus infection among population in Koryazhma and Arkhangelsk grew 1.5-1.6 times faster than epidemiological processes on the reference territory. Coliphages contents were equal to Р95in drinking water taken from centralized water supply systems in Arkhangelsk and Koryazhma, and it was 1.4 and 2.2 times higher respectively than the hygienic standard. Rotavirus, norovirus, and enterovirus infections were highly likely to occur in Arkhangelsk (R=0.97-0.99), and rotavirus infection, in Koryazhma (R=0.95). Average probability of norovirus infection (R=0.58) and enterovirus infection (R=0.43) was detected in Koryazhma. The research results indicate that Quantitative Microbial Risk Assessment (QMRA) procedure is feasible and significant within the system of sanitary-epidemiologic surveillance over water treatment; it substantiates the necessity to create and implement virology monitoring over centralized drinking water supply.

drinking water, water supply, acute intestinal infections, viral infections, coliphages contents, risk assessment, microbiological risk, QMRA
Baydakova E.V., Unguryanu T.N., Mikhaylova R.I. On quantitative assessment of microbe risk caused by exposure to enteric viruses in drinking water. Health Risk Analysis, 2019, no. 2, pp. 108–114. DOI: 10.21668/health.risk/2019.2.12.eng
  1. Rakhmanin Yu.A., Mikhailova R.I., Kamenetskaya D.B. Kachestvo pit'evogo vodosnabzheniya v Rossiiskoi Federatsii [Quality of drinking water supply in the Russian Federation]. Kontrol' kachestva produktsii, 2015, no. 9, pp. 7–13 (in Russian).
  2. Ebacher G., Besner M.C., Clément B., Prévost M. Sensitivity analysis of some critical factors affecting simulated in-trusion volumes during a low pressure transient event in a full-scale water distribution system. Water Research, 2012, vol. 46, no. 13, pp. 4017–4030.
  3. Lambertini E., Borchardt M.A., Kieke B.A. Jr., Spencer S.K., Loge F.J. Risk of viral acute gastrointestinal illness from nondisinfected drinking water distribution systems. International Journal of Environmental Science and Technology, 2012, vol. 46, no. 17, pp. 9299–9307.
  4. Ford T.E. Microbiological safety of drinking water: United States and global perspective. Environmental Health Perspectives, 1999, vol. 107, no. 1, pp. 191–206.
  5. Hellard M.E., Sinclair M.I., Forbes A.B., Fairley C.K. A randomized, blinded, controlled trial investigating the gastro-intestinal health effects of drinking water quality. Environmental Health Perspectives, 2001, vol. 109, no. 8, pp. 773–778.
  6. Holeton C., Chambers P.A., Grace L. Wastewater release and its impact on Canadian waters. Canadian Journal of Fisheries and Aquatic Sciences, 2011, vol. 68, pp. 1836–1869.
  7. Petterson S.R. Application of a QMRA Framework to Inform Selection of Drinking Water Interventions in the Developing Context. Risk Analysis: An Official Publication Of The Society For Risk Analysis, 2016, vol. 36, no. 2, pp. 203–214.
  8. Bergion V., Lindhe A., Sokolova E., Rosén L. Risk-based cost-benefit analysis for evaluating microbial risk mitigation in a drinking water system. Water Research, 2018, vol. 132, pp. 111–123.
  9. Nedachin A.E., Dmitrieva R.A., Doskina T.V., Dolgin V.A. The illustrative value of separate indices and markers for viral contamination of water. Gigiena i sanitariya, 2015, vol. 94, no. 6, pp. 54–58 (in Russian).
  10. Petterson S.R., Stenström T.A., Ottoson J. A theoretical approach to using faecal indicator data to model norovirus concentration in surface water for QMRA: Glomma River, Norway. Water Research, 2016, vol. 91, pp. 31–37.
  11. Howard G., Pedley S., Tibatemwa S. Quantitative microbial risk assessment to estimate health risks attributable to water supply: can the technique be applied in developing countries with limited data? Journal of Water and Health, 2015, vol. 4, no. 1, pp. 49–65.
  12. Griffith J.F., Weisberg S.B., Arnold B.F., Cao Y., Schiff K.C., Colford J.M. Jr. Epidemiologic evaluation of multiple alternate microbial water quality monitoring indicators at three California beaches. Water Research, 2016, vol. 94, pp. 371–381.
  13. Soller J.A., Schoen M., Steele J.A., Griffith J.F., Schiff K.C.Incidence of gastrointestinal illness following wet weather recreational exposures: Harmonization of quantitative microbial risk assessment with an epidemiologic investigation of surfers. Water Research, 2017, vol. 121, pp. 280–289.
  14. Quantitative microbial risk assessment: application for water safety management. WHO Library Cataloguing-in-Publication Data. World Health Organization, 2016, pp. 12–13. Available at: https://apps.who.int/iris/bit¬stream/han-dle/10665/246195/9789241565370-eng.pdf (25.12.2018).
  15. Borrego J.J., Cornax R., Morinigo M.A., Martinez-Manzanares E., Romero P. Coliphages as an indicator of faecal pollution in water. Their survival and productive infectivity in natural aquatic environment. Water Research, 1991, vol. 24, pp. 111–116.
  16. Stetler R.E. Coliphages as indicators of enteroviruses. Applied and Environmental Microbiology, 1984, vol. 48, pp. 668–670.
  17. Stalkup J.R., Chilukuri S. Enterovirus infections: a review of clinical presentation, diagnosis, and treatment. Dermatologic clinics, 2006, vol. 20, no. 2, pp. 217–223.
  18. Ward R.L., Bernstein D.I., Young E.C., Sherwood J.R., Knowlton D.R., Schiff G.M. Human rotavirus studies in vol-unteers: determination of infectious dose and serological response to infection. The Journal of Infectious Diseases, 1986, vol. 154, no. 5, pp. 871–880.
  19. Teunis P.F., Moe C.L., Liu P., Miller S.E., Lindesmith L., Baric R.S. [et al.]. Norwalk virus: how infectious is it? Journal of Medical Virology, 2008, vol. 80, no. 8, pp. 1468–1476.
  20. Mel'tser A.V., Kiselev A.V., Erastova N.V. Hygienic validation of assessment of drinking water quality in terms of ep-idemiological safety using methodology of public health risk assessment. Profilakticheskaya i klinicheskaya meditsina, 2015, no. 3 (56), pp. 12–17 (in Russian).

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