NK-cells that identify glycopatterns and their anti-tumor potential against a background of epidemically significant viral infections

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PDF icon health-risk-analysis-2019-1-16.pdf
UDC: 
617.741-004.1-053.9
DOI: 
10.21668/health.risk/2019.1.16.eng
Authors: 

M.V. Lakhtin, V.М. Lakhtin, V.А. Aleshkin, S.S. Afanasiev

Organization: 

G.N. Gabrichevskiy's Moscow Scientific Research Institute for Epidemiology and Microbiology, 10 Admirala Makarova Str., Moscow, 212125, Russian Federation

Abstract: 

Risks related to tumors development against a background of viral infections as well as factors that determine such risks or reduce them have not been examined profoundly so far. Our research goal was to accomplish a scientific review of research on a potential possessed by populations of lectin NK-cells (natural killers) in a body; such populations can have variable sets of lectin and other functionally significant cell surface receptors against tumors in a situation when viruses, including epidemically significant ones, penetrate a body. It is shown that co-functioning of various receptors and their ligands that redistribute cytokines (glycopattern-identifying lectin (basis) receptors, Ig-similar receptors, cytotoxic receptors, and other effector (adjusting) receptors) plays a significant role in intercellular communications and effects produced by NK-populations. NK-populations network is a promising resource for body protection and it should be taken into account when developing new anti-tumor and anti-viral preventive and medical strategies. When certain NK-populations with protective functions are absent in a body, it can be considered a new multi-factor risk of viral and oncologic diseases in an individual or a contingent living in a specific region. The reviewed data can be applied to develop new anti-tumor and anti-viral medications and vaccines as well as medical strategies. Probiotic lectins are promising ligands of intercellular communications associated with immune surveillance.

Keywords: 
viral infections, tumors, multi-factor disease, risk factors, receptor lectins, NK-cells, anti-tumor strategies
Lakhtin M.V., Lakhtin V.М., Aleshkin V.А., Afanasiev S.S. NK-cells that identify glycopatterns and their anti-tumor potential against a background of epidemically significant viral infections. Health Risk Analysis, 2019, no. 1, pp. 144–153. DOI: 10.21668/health.risk/2019.1.16.eng
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Received: 
18.10.2018
Accepted: 
26.01.2019
Published: 
30.03.2019

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