Risk factors and predicting health disorders in infants born from monocyesis after in vitro fertilization

View or download the full article: 
PDF icon health-risk-analysis-2017-1-7.pdf
UDC: 
616-053.36- 092.11-036: 618.177-089.888.11
DOI: 
10.21668/health.risk/2017.1.07.eng
Authors: 

L.A. Pykhtina, O.M. Filkina, N.D. Gadzhimuradova, A.I. Malyshkina, S.B. Nazarov

Organization: 

Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkova, 109 Shuvandina Str., Ivanovo, 153045, Russian Federation

Abstract: 

Issues of health state and factors determining it in infants born due to in vitro fertilization (IVF) have been frequently discussed over recent years. The question yet to be answered is whether health disorders are related to burdened pre-morbid state of a mother as per extragenital and obstetric-gynecologic pathology or they are caused by IVF. Selective transfer of only one embryo has tended to increase recently, and, given this trend, specialists all around the world, and in our country as well, face a problem of detecting risk factors which cause health disorders in children born in monocyesis after IVF. Prognostic algorithm for most frequent pathologies is being worked out and it will help to implement targeted and differentiated approach to their prevention. We have completed clinical examination of infants during the first year of their life; all these infants were born in monocyesis after IVF (n=121). We have also questioned and interviewed their parents and analyzed data taken from infants' development records over a year as well. We have applied Wald sequential mathematical analysis to determine risk factors and create prognostic tables comprising most frequent somatic health disorders such as congenital abnormalities, iron-deficiency anemia, atopic dermatitis, absence of perinatal CNS damage compensation. We have detected that factors related to a mother's and newborn's health (extragenital morbidity, obstetric-gynecologic case history, pregnancy course) exert their influence on health disorders evolvement in such children during their first year of life; we have also shown that social factors and factors associated with IVF procedure don't have any statistical significance.

Keywords: 
risk factors, health disorders prediction, children from monocyesis, IVF, congenital abnormalities, iron-deficiency anemia, atopic dermatitis, perinatal CNS damages
Pykhtina L.A., Filkina O.M., Gadzhimuradova N.D., Malyshkina A.I., Nazarov S.B. Risk factors and predict-ing health disorders in infants born from monocyesis after in vitro fertilization. Health Risk Analysis, 2017, no. 1, pp. 56–65. DOI: 10.21668/health.risk/2017.1.07.eng
References: 
  1. Baranov A.A. Spravka o sostoyanii zdorov'ya detei, rodivshikhsya v rezul'tate ispol'zovaniya vspomoga-tel'nykh reproduktivnykh tekhnologii, v tom chisle EKO [Information on health state of children born due to as-sisted reproductive technologies including IVF]. Soyuz pediatrov Rossii. Available at: http://www.pediatr-russia.ru/node/124 (02.10.2016) (in Russian).
  2. Vartanyan E.V. Vozmozhnosti preodoleniya povtornykh neudach v protsedurakh vspomogatel'nykh re-produktivnykh tekhnologii [Overcoming the Possibility of Repeated IVF Failure]. Vestnik Ural'skoi meditsinskoi akademicheskoi nauki, 2013, vol. 45, no. 3, pp. 56–62 (in Russian).
  3. Gubler E.V. Vychislitel'nye metody analiza i raspoznavaniya patologicheskikh protsessov [Computa-tional techniques of pathologic processes analysis and recognition]. Leningrad, Meditsina Publ., 1978, 94 p. (in Russian).
  4. Zhirnov V.A., Dmitrieva M.V., Rustyanova D.R. Analiz somaticheskogo statusa novorozhdennykh detei, zachatykh posredstvom ekstrakorporal'nogo oplodotvoreniya [Analyzing somatic state of newborns, conceived via IVF]. Molodoi uchenyi: vyzovy i perspektivy: materialy VI Mezhdunarodnoi nauchno-prakticheskoi konferentsii [Young scientist: challenges and prospects: materials of VI International theoretical and practical conference]. In: N.R. Krasovskaya ed. Moscow, 2016, pp. 67–71 (in Russian).
  5. Zdanovskii V.M., Vityazeva I.I. Techenie i iskhod beremennostei posle lecheniya besplodiya metodami vspomogatel'noi reproduktsii (MVR) [Pregnancy course and outcome after treating infertility with assisted reproductive technologies]. Problemy reproduktsii, 2000, no. 3, pp. 55–56 (in Russian).
  6. Gadzhimuradova N.D., Pykhtina L.A., Fil'kina O.M., Malyshkina A.I. Zdorov'e detei, rozhdennykh posle primeneniya ekstrakorporal'nogo oplodotvoreniya, i ikh materei [The health of children born after extracorporeal fertilization and their mother`s health]. Vrach-aspirant, 2015, vol. 71, no 4, pp. 51–56 (in Russian).
  7. Evert L.S., Galonskii V.G., Tepper E.A., Volynkina A.I., Tarasova N.V. Iskhody beremennosti i sostoyanie zdorov'ya detei, rozhdennykh posle primeneniya vspomogatel'nykh reproduktivnykh tekhnologii [Pregnancy outcomes and health of children born following assisted reproductive technologies] Sibirskii meditsinskii zhurnal (g. Tomsk), 2013, vol. 28, no. 1, pp. 65–69 (in Russian).
  8. Kalinina E.A., Alieva K.U., Strel'chenko M.B. Nauchno-klinicheskii analiz raboty otdeleniya vspomoga-tel'nykh tekhnologii v lechenii besplodiya v 2011 godu [Clinico-scientific analysis summarizing the work of the department for assisted reproductive technology for the year 2011]. Akusherstvo i ginekologiya, 2013, no. 1, pp. 81–84 (in Russian).
  9. Kinsht D.A., Soboleva M.K., Aizikovich I.V. Zdorov'e novorozhdennykh ot odnoplodnoi indutsirovannoi beremennosti: sobstvennyi opyt nablyudeniya MTs «Avitsenna» [The health of infants from singleton induced pregnancy: own experience of observing medical center «Avicenna»]. Reproduktivnaya meditsina, 2014, vol. 20, no. 3–4, pp. 18–23 (in Russian).
  10. Korsak V.S., Vasil'eva O.V., Isakova E.V. Endometrioz i VRT (obzor literatury) [Endometriosis and ART (literature overview)]. Problemy reproduktsii, 2006, no. 3, pp. 41–46 (in Russian).
  11. Korsak V.S., Smirnova A.A., Shurygina O.V. Registr tsentrov VRT v Rossii. Otchet za 2011 god [ART centers register in Russia. 2011 report]. Problemy reproduktsii, 2013, no. 5, pp. 7–16 (in Russian).
  12. Krasnopol'skaya K.V., Kabanova D.I., Kalugina A.S. Effektivnost' ekstrakorporal'nogo oplodotvoreniya u patsientok s sindromom polikistoznykh yaichnikov i yaichnikovoi giperandrogeniei [IVF efficiency in patients suffering from polycystic ovary syndrome and ovarian hyperandrogenism]. Akusherstvo i ginekologiya, 2003, no. 1, pp. 57–61 (in Russian).
  13. Krasnoshchoka O.E., Smol'nikova V.Yu., Kalinina E.A. Klinicheskie i embriologicheskie aspekty selektiv-nogo perenosa odnogo embriona [Clinical and embryological aspects of elective single embryo transfer]. Problemy reproduktsii, 2015, vol. 21, no. 2, pp. 51–57 (in Russian).
  14. Krstich E.V., Krasnopol'skaya K.V., Kabanova D.I. Novye podkhody k povysheniyu effektivnosti EKO u zhenshchin starshego reproduktivnogo vozrasta [New approaches to enhancing THE EFFICIENCY OF in vitro fertilization in old reproductive age women]. Akusherstvo i ginekologiya, 2010, no. 2, pp. 48–53 (in Russian).
  15. Lysenko A.V., Markelova M.I., Sudakova N.M. Analiz faktorov riska beremennosti i rannego neonat-al'nogo perioda novorozhdennykh posle vspomogatel'nykh reproduk¬tivnykh tekhnologii [Analyzing risk factors for pregnancy and early neonatal period of newborns after assisted reproductive technologies]. Sovremennye nauchnye issledovaniya i innovatsii, 2013, no. 1. Available at: http://web.snauka.ru/issues/2013/01/19773 (10.10.2016) (in Russian).
  16. Maslyanyuk N.A. Sostoyanie novorozhdennykh detei i ikh dal'neishee razvitie pri mnogoplodnoi bere-mennosti posle ekstrakorporal'nogo oplodotvoreniya: avtoref. dis. … kand. med. nauk [Newborns state and their further development at multiple pregnancy after IVF: abstract of a thesis … candidate of medical sciences]. St. Petersburg, 2005, 24 p. (in Russian).
  17. Mikheeva E.M., Penkina N.I. Zdorov'e detei, rozhdennykh s ispol'zovaniem vspomogatel'nykh reproduk-tivnykh tekhnologii [The health status of children conceived with assisted reproductive technologies]. Prakti-cheskaya meditsina, 2014, vol. 85, no. 9, pp. 47–51 (in Russian).
  18. Vyalikova Yu.V., Alieva A.Ya., Naiko Yu.V., Shintaev T.K. Osobennosti beremennosti i rodov u patsien-tok posle ekstrakorporal'nogo oplodotvoreniya [Peculiarities of pregnancy and labor in patients after IVF]. Byulle-ten' meditsinskikh internet-konferentsii, 2015, vol. 5, no. 5, pp. 442 (in Russian).
  19. Shchetinina N.S., Kuz'michev L.N., Burlev V.A., Onishchenko A.S., Il'yasova N.A. Otsenka effektivnosti programmy EKO: den' perenosa embrionov v polost' matki i pokazateli kontroliruemoi induktsii ovulyatsii [As-sessment of IVF/ICSI efficasy: the day of embryo transfer and parameters of controlled ovarian hyperstimula-tion]. Problemy reproduktsii, 2011, no. 3, pp. 56–61 (in Russian).
  20. Plaksina A.N. Prognozirovanie zdorov'ya i kachestva zhizni detei, rozhdennykh s pomoshch'yu vspomo-gatel'nykh reproduktivnykh tekhnologii: dis. … kand. med. Nauk [Predicting health and life quality for children, born due to assisted reproductive technologies: abstract of a thesis … candidate of medical sciences]. Ekaterinburg, 2011, 174 p. (in Russian).
  21. Saidova R.A., Guseinova Z.S. Znachenie predgravidarnoi podgotovki v profilaktike sindroma poteri ploda u bol'nykh s giperandrogeniei [Pregravid preparation in prophylaxis of syndrome of fetus loss in patients with hyperandrogenism]. Problemy zhenskogo zdorov'ya, 2011, vol. 6, no. 1, pp. 25–30 (in Russian).
  22. Rudakova E.B., Loboda O.A., Poltoraka E.V., Burova O.M., Pilipenko M.A. Faktory riska neudach i em-brionicheskikh poter' pri ekstrakorporal'nom oplodotvorenii [Risk factors of failures and embryonic losses under in vitro fertilization]. Sibirskii meditsinskii zhurnal (g. Tomsk), 2008, vol. 23, no. 4–1, pp. 14–17 (in Russian).
  23. Fil'kina O.M., Pykhtina L.A., Vorob'eva E.A., Kocherova O.Yu., Dolotova N.V., Shanina T.G. Faktory riska otklonenii fizicheskogo razvitiya u detei rannego vozrasta s perinatal'nymi porazheniyami tsentral'noi nervnoi sistemy [The risk factors of dapartures in physical development in children of early age with perinatal affection of central nervous system]. Lechenie i profilaktika, 2015, vol. 13, no. 1, pp. 16–21 (in Russian).
  24. Källén B., Finnström O., Lindam A., Nilsson E., Nygren Karl-Gösta, Olausson P.O. Cancer risk in children and young adults conceived by in vitro fertilization. Pediatrics, 2010, vol. 126, pp. 270–276.
  25. Elective single embryo transfer. Fertil Steril, 2012, vol. 97, no. 4, pp. 835–842. Available at: https://www.asrm.org/Elective_Single_Embryo_Transfer/ (15.10.2016)
  26. Gelbaya T.A., Tsoumpou I., Nardo L.G. The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage: a systematic review and meta-analysis. Fertility and Sterility, 2010, vol. 94, no. 3, pp. 936–945.
  27. Pandey S., Shetty A., Hamilton M., Bhattacharya S., Maheshwari A. Obstetric and perinatal outcomes in singleton pregnnancies resulting from IVF/ ICSI: a systematic review and metaanalysis. Hum. Reprod. Update, 2012, vol. 18, no. 5, pp. 485–503. DOI: 10.1093/humupd/dms018.
  28. Zhu J.L., Hvidtjørn D., Basso O., Obel C., Thorsen P., Uldall P., Olsen J. Parental infertility and cerebralpalsy in children. Human Reproduction, 2010, vol. 25, no. 12, pp. 3142–3145. DOI: 10.1093/humrep/deq206
  29. Gosden R., Trasler J., Lucifero D., Faddy M. Rare congenital disorders, imprinted genes, and assisted re-productive technology. Lancet, 2003, vol. 361, pp. 1975–1977.
  30. Tararbit K., Lelong N., Thieulin A.-C., Houyel L., Bonnet D., Goffinet F., Khoshnood B. The risk for four specific congenital heart defects associated with assisted reproductive techniques: a population-based evaluation. Human Reproduction, 2013, vol. 28, pp. 367–374.
  31. World Population Prospects: The 2015 Revision: Key Findings and Advans Tables. New York, United Na-tions, 2015. Available at: https://esa.un.org/unpd/wpp/publications/files/key_findings_wpp_2015.pdf (18.10.2016).

You are here

Home