Assessment of the airborne phthalate exposure on lung function of preschool and primary school children

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DOI: 
10.21668/health.risk/2016.1.06.eng
Authors: 

T.S. Ulanova1,2, T.D. Karnazhitskaya1, E.O. Zavernenkova1

Organization: 

1 FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”, 82 Monastyrskaya St., Perm, Russian Federation, 614045
2 FBSEI HPE “Perm National Research Polytechnic University”, Komsomolsky Av. 29, Perm, Russian Federation, 614990

Abstract: 

The results of the studies of phthalates’ content in the indoor and outdoor air on the territory of pre-school and school educational institutions, the definition of phthalates metabolites in the urine and parameters of lung function of children attending these institutions are presented in the work. The HPLC/MS method detected the presence of 4 phthalates in 7 analyzed rooms and the air of pre-school and school facilities in the range 0.0002–0.00116 mg/m 3 concentrations. The method of HPLC/MS/TFE metabolites detected the presence of phthalate (monometylphtalate, monobutylphtalate, monohexylilphtalate) in the urine of children in the concentration range of 0.00039–0.012 mg/m 3 . Analysis of dependencies of "the concentration of phthalate metabolites in the urine – the parameters of pulmonary function" revealed a statistically significant correlation coefficients (p < 0.05) of directly proportional dependency of Gensler index (FEV1/SVC) and instantaneous space velocity (MEF 25, 50, 75) on the concentration of monophtalates in urine of the girls. A statistically significant correlation of coefficients (p < 0.05) inversely proportional to the forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and the instantaneous volume velocity after exhaling 50 % (MEF 50) from monophtalates’ concentration in the boys’ urine.

Keywords: 
phthalates monometylphtalate, monobutylphtalate, monobenzylphtalate, mono-2-ethylhexylphthalate, high performance liquid chromatography / mass spectrometry, atmospheric air, lung function parameters
Ulanova T.S., Karnazhitskaya T.D., Zavernenkova E.O. Assessment of the airborne phthalate exposure on lung function of preschool and primary school children. Health Risk Analysis, 2016, no. 1, pp. 50-58. DOI: 10.21668/health.risk/2016.1.06.eng
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