Characterization of the genotypes of children and adults residing in the conditions exposed to the chemical risk factors

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DOI: 
10.21668/health.risk/2015.1.07.eng
Authors: 

О.V. Dolgikh1,2,3, А.V. Krivtzov1, О.А. Bubnova1,3, K.G. Starkova1, V.А. Luchnikova1, Е.А. Pirogova1

Organization: 

1 FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies", Russian Federation, Perm, 82, Monastyrskaya St., 614045,
2 Perm National Research Polytechnic University, Russian Federation, Perm, 29, Komsomolsky prospekt, 614990,
3 Perm State National Research University, Russian Federation, Perm, 15, Bukireva St., 614990

Abstract: 

We conducted the comparative assessment of the results of immune diagnostics and analysis of polymorphism of genes in children exposed to the aero-technogenic contaminants with the genotypes of their parents. We established the genetic polymorphism of detoxication genes CYP1A1, CPOX, SULT1A1 as well as the alternative allelism of genes characterizing the condition of the endothelium of vessels (VEGF and eNOS) both for children and their parents. The presented data evidence the genetic fixation of minor genotypes of parents in children exposed to the chemical risk factors.

Keywords: 
aerogenic external environmental load, polymorphism of genes, genetic fixation, detoxication genes, risk factors
Dolgikh О.V., Krivtzov А.V., Bubnova О.А., Starkova K.G., Luchnikova V.А., Pirogova Е.А. Characterization of the genotypes of children and adults residing in the conditions exposed to the chemical risk factors. Health Risk Analysis, 2015, no. 1, pp. 55-59. DOI: 10.21668/health.risk/2015.1.07.eng
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