Peculiarities of epicutaneous action of hexyl ether of 5-aminolevulinic acid

View or download the full article: 

Е.K. Vlasenko, S.I. Sychik, I.I. Ilyukova, V.А. Stelmakh, V.А. Grynchak


RUE “Scientific Practical Centre of Hygiene” of the Ministry of Health of the Republic of Belarus, the Republic of Belarus, 220012, Minsk, Academicheskaya St., 8


We studied the subacute toxicity of hexyl ether of 5-aminolevulinic acid at the epicutaneous action in the experiment with white rats. It was established that repeated application of hexyl ether of 5-aminolevulinic acid cause the weak reaction of the white rats skin in the form of edema. The transdermal hexyl ether of 5-aminolevulinic acid intake route is characterized by the increase in the alanine aminotransferase activity, the level of urea in the blood serum and shift to the acid side of pH in the urine of experimental animals. The exposure dose of 341 mg/kg is the dose acting with minimum deviations of values and is accepted as threshold. The exposure dose of 75 mg/kg does not cause the changes in the condition of laboratory animals and is the maximum inactive dose.

toxicity, hexyl ether of 5-aminolevulinic acid, epicutaneous impact
Vlasenko Е.K., Sychik S.I., Ilyukova I.I., Stelmakh V.А., Grynchak V.А. Peculiarities of epicutaneous action of hexyl ether of 5-aminolevulinic acid. Health Risk Analysis, 2015, no. 1, pp. 49-54. DOI: 10.21668/health.risk/2015.1.06.eng
  1. Kishkun A.A. Rukovodstvo po laboratornym metodam diagnostiki [Guidance on laboratory methods for diagnosis]. Moscow, GJeOTAR-Media, 2007, 822 р.
  2. Stimuljacija rosta i razvitija rastenij jachmenja lipofil'nymi jefirami 5-aminolevulinovoj kisloty [Stimula-tion of plant growth and development of barley lipophilic esters of 5-aminolevulinic acid]. S.G. Spivak, E.B. Ja-ronskaja, I.V. Vershilovskaja, V.Ju. Davydov, I.V. Trostjanko, V.I. Dolgopalec, N.G. Averina, M.A. Kisel'. Dokl. Nac. akad. nauk Belarusi, 2007, vol. 51, no 5, рр. 95–99.
  3. Trebovanija k postanovke jeksperimental'nyh issledovanij dlja pervichnoj toksikologicheskoj ocenki i gi-gienicheskoj reglamentacii veshhestv: instrukcija [Requirements for the formulation of experimental studies for primary toxicological evaluation and hygienic materials: User:]. utv. Ministerstvom zdravoohranenija Resp. Bela-rus' 14.12.04. Minsk, 2004, 43 р.
  4. Averina, N.G. Involvement of 5-aminolevulinic acid in the regulation of plant growth. N.G. Averina, E.B. Yaronskaya. Photosynthetica, 1991, vol. 25, no 1, рр. 27–31.
  5. Beale, S.I. Biochemistry and regulation of photosynthetic pigment formation in plants and algae. S.I. Beale and J.D. Weinstein. Biosynthesis of Tetrapyrroles (New Comprehensive Biochemistry Series). Ed.: P.M. Jor-dan. – Elsevier, Amsterdam, The Netherlands, 1991, vol. 19, рр. 155–235.

You are here