Effects of subchronic exposure manganese oxide nanoparticles on the central nervous system, lipid peroxidation and antioxidant enzymes in rats

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UDC: 
615.9, 614.7
DOI: 
10.21668/health.risk/2014.4.09.eng
Authors: 

N.V. Zaitseva1, М.А. Zemlyanova1, V.N. Zvezdin1, Т.I. Akafyeva2, D.L. Mazunina2, А.А.Dovbish1

Organization: 

1 FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”, Russian Federation, Perm, 82, Monastyrskaya St., 614045,
2 FSBEI HPE «Perm State National Research University", Russian Federation, Perm, 15, Bukireva St., 614990

Abstract: 

Nanodisperse particles of manganese oxide (MnO) by virtue of high reactivity are widely used as an active substance in the manufacture of sorbents and catalysts used in the liquid waste disposal technology. Receipt of MnO in the composition of wastewater into free waters, which are sources of drinking water supply, is a potential danger to human health. However, the consequences of the MnO effects on the human body by ingestion with drinking water have hardly been studied. The study estimated changes in activity indices of lipid peroxidation and antioxidant defense, balance of neurotransmitters in the central nervous system in the blood serum after oral gavage Wistar aqueous suspension of nanodiperse MnO particle in size of 15-29 nm to the rats. Doses of MnO 260, 50, 10 and 5 mg / kg body weight / day was administered daily for 7 days for 90 days. It is shown that the MnO causes lipid peroxidation (by raising of lipid hydroperoxides and malondialdehyde in the serum) and reduced activity antioksidatnoy system (bu reducing the total antioksidatnogo status and Cu / Zn-superoxide dismutase in the serum). It is found a violation of the ratio of neurotransmitter glutamate to increase and decrease the level of γ-aminobutyric acid in the blood serum. At a dose of 5 mg / kg per day nanodisperse MnO does not cause these effects. Found negative effects are confirmed by morphological changes in the brain tissue (in the cerebral hemisphere and cerebellum).

Keywords: 
manganese oxide, nanoparticles, brain. neurotoxicity, ox stress, antioxidant activity
Zaitseva N.V., Zemlyanova М.А., Zvezdin V.N., Akafyeva Т.I., Mazunina D.L., Dovbish А.А. Effects of subchronic exposure manganese oxide nanoparticles on the central nervous system, lipid peroxidation and antioxidant enzymes in rats. Health Risk Analysis, 2014, no. 4, pp. 66-77
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