Risk of reproductive system pathology in women–colourers contacting with aromatics hydrocarbons

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UDC: 
575.174.015.3:[613632+616-057]
DOI: 
10.21668/health.risk/2014.3.06.eng
Authors: 

S.V. Fedorovich1, L.M. Shevchuk1, A.G. Markova1, O.D. Levdansky2

Organization: 

1 RUE «Scientific Practical Center of Hygiene», Republic of Belarus, 8, Akademicheskaya St., Minsk, 220012
2 Institute of genetics and cytology, National Academy of Sciences of Belarus, Republic of Belarus, Minsk, 27, Akademicheskaya St., 220072

Abstract: 

Genetic polymorphism of xenobiotics’ metabolism enzymes is the most important factor determining individual sensibility of organism to harmful chemical substances of production environment. This factor generates the predisposition to occupational pathology. The performed studies have indicated that maximum risk for reproductive system pathology in women-colourers, contacting with aromatics hydrocarbons, is stipulated by the absence of the activity of the enzymes of glutathione-transferase Т1 and glutathione-transferase М1 encoded by genes (genotype GSTM1«0»/GSTT1«0»).

Keywords: 
gene of xenobiotics’ biotransformation; glutathione-transferase; genetic polymorphism; reproductive system diseases
Fedorovich S.V., Shevchuk L.M., Markova A.G., Levdansky O.D. Risk of reproductive system pathology in women–colourers contacting with aromatics hydrocarbons. Health Risk Analysis, 2014, no. 3, pp. 51-55
References: 
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  2. Spicyn A.V. Polimorfizm v genah cheloveka, associirujushhihsja s biotransformaciej ksenobiotikov [Polymorphism in human genes associated with xenobiotics biotransformation]. Vestnik Vavilovskogo obshhestva genetikov i selekcionerov, 2006, vol. 10, no. 1, pp. 97–105.
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