Comparison of toxicity of aqueous suspension of nano-and microfine silica in subchronic experiment

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UDC: 
615.9, 614.7
DOI: 
10.21668/health.risk/2014.1.09.eng
Authors: 

M.A. Zemlyanova1, V.N. Zvezdin1, A.A. Dovbysh1, T.I. Akafyeva1,2

Organization: 

1 FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”, 82, Monastyrskaya St., Perm, 614045, Russia,
2 FSBEI HPE “Perm State National Research University”, 15, Bukireva St., Perm, 614990, Russia

Abstract: 

In subchronic experiment on Wistar’s white male rats the negative effects have been studied and the comparative assessment of toxicity of an aqueous suspension of nano- and microfine silicon dioxide has been carried out. It was found that by intragastric administration for 90 days of the dose of 14.6 mg/kg, corresponding to the predicted threshold dose (LOAEL), the aqueous suspension of nanosized silicon dioxide causes immune irritating, cytolytic and inflammatory effects, verified by the deviation of hematologic parameters and morphological changes in tissues bodies / or target systems (liver, stomach, jejunum and colon, immune system). Micro-sized silica causes predominantly an inflammatory effect in the mucosa of stomach, jejunum and colon.

Keywords: 
silica nanoparticles, microparticles, negative effects, subchronic toxicity, intragastric administration, experimental studies
Zemlyanova M.A., Zvezdin V.N., Dovbysh A.A., Akafyeva T.I. Comparison of toxicity of aqueous suspension of nano-and microfine silica in subchronic experiment. Health Risk Analysis, 2014, no. 1, pp.74-82
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