Characteristics of gene polymorphism in women with a threat of miscarriage and airborne exposure to phenols

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PDF icon health-risk-analysis-2013-4-10.pdf
UDC: 
613.64: 616.717 – 057
DOI: 
10.21668/health.risk/2013.4.10.eng
Authors: 

O.V. Dolgikh1,2,3, A.V. Krivtsov1, O.A. Bubnova3, V.B. Alexeyev1,3

Organization: 

1 FBSI «Federal Scientific Center for Medical and Preventive Health Risk Management Technologies», Russian Federation, Perm, 82 Monastyrskaya St., 614045,
2 Federal State Budget Educational Institution of Higher Professional Education «Perm National Research Polytechnic University», Russian Federation, Perm, 29 Komsomolskiy Ave, 614990,
3 Federal State Budget Educational Institution of Higher Professional Education «Perm State National Research University», Russian Federation, Perm, 15 Bukireva St., 614990

Abstract: 

The performed assessment of the results of gene diagnostics revealed characteristics of gene polymorphism of detoxification genes and of CYP1A1, CPOX, SULT1A1 and ESR1 reproduction. The determined genetic characteristicsinclude mostly mutations of genes responsible for enzyme detoxification and are definedmainly by differences in the frequency of heterozygotes. The presented data suggestan association between genes and a threat of miscarriage under exposure to phenols.

Keywords: 
phenols, threat of miscarriage, detoxification genes, estrogen receptor 1 gene
Dolgikh O.V., Krivtsov A.V., Bubnova O.A., Alexeyev V.B. Characteristics of gene polymorphism in women with a threat of miscarriage and airborne exposure to phenols. Health Risk Analysis, 2013, no. 4, pp. 77-81
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